Publications by authors named "Neal Rimmer"
The Parkinson's disease (PD) risk gene GTP cyclohydrolase 1 (GCH1) catalyzes the rate-limiting step in tetrahydrobiopterin (BH4) synthesis, an essential cofactor in the synthesis of monoaminergic neurotransmitters. To investigate the mechanisms by which GCH1 deficiency may contribute to PD, we generated a loss of function zebrafish mutant (), using CRISPR/Cas technology. zebrafish develop marked monoaminergic neurotransmitter deficiencies by 5 d postfertilization (dpf), movement deficits by 8 dpf and lethality by 12 dpf.
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- - The study investigates the role of the histamine H3 receptor (Hrh3) in aggression behavior using a zebrafish model, revealing its significant impact on aggression and anxiety levels.
- - Researchers created a Hrh3 null mutant line using CRISPR and analyzed changes in behavior and neural activity through imaging techniques, finding that inactivation of Hrh3 leads to reduced aggression and increased anxiety.
- - The findings suggest that Hrh3 signaling is crucial for aggression and anxiety regulation, indicating potential therapeutic targets for addressing similar human conditions characterized by heightened aggression.