P27 and mib1 expression in actinic keratosis, Bowen disease, and squamous cell carcinoma.

The histologic boundary between actinic keratosis, Bowen disease, and invasive squamous cell carcinoma is not clear in many cases. We determined nuclear expression of p27 (a protein associated with cellular quiescence) and Ki-67 (a marker of proliferation) immunohistochemically in actinic keratosis, Bowen disease, and squamous cell carcinoma to see if differential patterns of expression for p27 exist and how these might correlate with Ki-67 expression. We determined a labeling index for p27-stained nuclei and assessed the pattern of Ki-67 expression.

The incidence of nonattendance at an urgent care dermatology clinic.

Nonattendance in dermatology clinics remains a burden on clinic efficiency. Nonattendance rates have been measured in an urban university-based dermatology clinic and are significant. The nonattendance rate in a dermatology clinic dedicated primarily to new acute problems is not known.