Novel murine model for colon cancer: non-operative trans-anal rectal injection.

Background: This study was conducted to develop a modified murine model of colon cancer that is non-operative. Currently, the most accurate orthotopic murine model of colon cancer requires an invasive procedure involving cecal injection of colon cancer cells and therefore limits the ability to perform immunological studies subsequent to cecal resections.

Materials And Methods: Murine colon cancer (CT26) cells were injected submucosally into the distal, posterior rectum of BALB/c mice.