Publications by authors named "Neal C"

Erdheim-Chester disease (ECD) is a rare systemic histiocytic disease. The authors present a case report detailing the presentation and treatment of a 26-year-old man diagnosed with seizures and a well-circumscribed temporoparietal mass that had been demonstrated on imaging studies. Both preoperative and intraoperative diagnoses were consistent with a low-grade astrocytic neoplasm.

View Article and Find Full Text PDF

Pre-eclampsia results in oedema, hypertension and proteinuria, and is associated with increased vascular permeability. A number of studies have pointed to the existence of a circulating macromolecule that induces this endothelial dysfunction. To test whether this circulating factor could increase vascular permeability, we have measured the effect of dialysed human plasma from pregnant women with mild or severe pre-eclampsia (pre-eclamptic toxaemia).

View Article and Find Full Text PDF

Continuous (hourly) measurements of dissolved oxygen and chlorophyll (determined by fluorimetry) were made for an inter-linked lowland river and canal system. The dissolved oxygen data were used to estimate daily rates of re-aeration, photosynthesis and respiration, using a process-based analytical technique (the Delta method). In-situ fluorimeter measurements of chlorophyll were ground-truthed on a fortnightly basis using laboratory methanol extraction of chlorophyll and spectrophotometric analysis.

View Article and Find Full Text PDF

Until recently, the synthetic glucocorticoid dexamethasone was commonly used to lessen the morbidity of chronic lung disease in premature infants. This practice diminished as dexamethasone use was linked to an increased incidence of cerebral palsy and short-term neurodevelopmental delay. Of more concern is the fact that we know little regarding dexamethasone effects on long-term neurodevelopment.

View Article and Find Full Text PDF

Competitive comparative genome hybridisation (CCGH) to Saccharomyces cerevisiae DNA microarrays and quantitative real-time polymerase chain reaction (qRT-PCR) assays are used to examine the copy number of S. cerevisiae-like genes, at single gene resolution, of two bottom-fermenting lager yeast strains, CMBS-33 and 6701. Using the S.

View Article and Find Full Text PDF

The goal of this study was to evaluate the periareolar injection of technetium 99m sulfur colloid to identify axillary sentinel nodes and compare the number of sentinel lymph nodes identified with preoperative lymphoscintigraphy to intraoperative biopsy using a handheld gamma probe. A total of 104 consecutive patients diagnosed with invasive breast cancer participated in this prospective study, with 81 patients receiving an intradermal periareolar injection and 23 patients receiving an intradermal peritumoral injection of filtered technetium 99m sulfur colloid. Preoperative lymphoscintigraphy was performed for sentinel node mapping and localization.

View Article and Find Full Text PDF

Purpose: To evaluate efficacy and toxicity of the Duke University chemoirradiation regimen for locally advanced head-and-neck cancer in a regional community cancer center.

Methods And Materials: Between June 1998 and June 2002, 50 patients with Stage III or IVA squamous cell carcinoma of the head and neck were treated definitively with concurrent combined modality therapy (CMT). Patients received accelerated, hyperfractionated radiotherapy (AFRT), 1.

View Article and Find Full Text PDF

Superior semicircular canal dehiscence is a recently described condition resulting in pressure-induced vertigo in affected patients. The diagnosis is established with the appearance of characteristic electronystagmographic and neuroimaging findings. This condition is amenable to surgical treatment by resurfacing of the dehiscence in the defect in the middle cranial fossa floor with preservation of superior semicircular canal function.

View Article and Find Full Text PDF

Dexamethasone is commonly used to limit the severity of chronic lung disease in premature infants with severe respiratory distress syndrome. Recent literature has demonstrated an association between dexamethasone exposure in critically ill premature neonates and later development of cerebral palsy. However, the majority of children exposed to dexamethasone in the neonatal period do not develop cerebral palsy or global developmental delay, and other more subtle effects of early life glucocorticoid exposure may go unnoticed.

View Article and Find Full Text PDF

The use of recombinant hepatitis B vaccines has led to the effective prevention of hepatitis B infection and its chronic sequelae in immunocompetent individuals. Whilst rare, a variety of serious adverse effects have been reported following vaccination including cutaneous vasculitis in eight previous cases. We describe a case of Henoch-Schönlein purpura developing after hepatitis B vaccination.

View Article and Find Full Text PDF

Over the past decade a major initiative examined the chemical flux transfers from eastern UK Rivers to the North Sea as part of an ambitious community research programme, the Land Ocean Interaction Study (LOIS). In this paper, a compilation of data on flux and flux per unit area for five major river basins, the Tweed, the Wear, the Humber, the Great Ouse and the Thames is presented based on an extensive riverine monitoring programme within the LOIS. The compilation includes details on the fluxes of major, minor and trace elements as well as the nutrients and sediments.

View Article and Find Full Text PDF

The hydrochemical and physical functioning of UK river basins, estuaries and coastal waters through to the open sea are outlined in relation to British environmental research over the last ten or more years. An overview of a considerable body of published work is presented in the context of current findings and future research challenges. This is linked to this special issue of Science of the Total Environment 'Land Ocean Interaction: processes, functioning and environmental management: a UK perspective' for which this contribution provides a conclusion.

View Article and Find Full Text PDF

The distribution of boron in rivers across European Union countries is described. The data have been collected from national and international monitoring programmes. The data show a wide range of concentrations but only in a few instances do concentrations exceed environmental quality standards.

View Article and Find Full Text PDF

The socio-economic and ecological value of wetland ecosystems is widely acknowledged. As a result, considerable efforts are now being made to rehabilitate and in some cases recreate wetlands throughout Europe. An option for the restoration of worked-out peat pits is to establish reed beds.

View Article and Find Full Text PDF

Fluoride concentrations in eastern UK rivers (the Humber, Tweed, Wear, Great Ouse and Thames) are described based on information collected within the Land-Ocean Interaction Study (LOIS) and by the Environment Agency (EA) of England and Wales. The results show varied fluoride concentrations across the region, with a range from <0.01 to >10 mg l(-1); and mean, median and range in mean concentrations of 0.

View Article and Find Full Text PDF

The concentrations of beryllium (Be) in surface waters are presented for major water quality surveys of eastern UK rivers, based on extensive work within a major environmental programme, the Land Ocean Interaction Study (LOIS). Two measurements were made, one for dissolved Be (i.e.

View Article and Find Full Text PDF

This paper examines the temporal changes in dissolved beryllium in deposition (rainfall and cloud water), stream water and groundwater for the upper River Severn catchments at Plynlimon in mid-Wales. There are two main themes to the study. Firstly, time series records are examined to see if anomalous behaviour occurred during 1996, when remarkably high concentrations were unexpectedly observed in the UK lowland rivers (Neal, Sci Total Environ, 2003).

View Article and Find Full Text PDF

An extensive study of acidic and acid sensitive moorland and forested catchments in mid-Wales is used to show the water quality functioning with respect to nitrate and ammonium. For this, long-term records of rainfall, cloud water, throughfall, stemflow and stream water (up to 18 years of weekly data) are combined with shorter duration information on stream water associated with small tributary sources and drainage ditches, ground water from a network of exploratory boreholes and paired control and felled catchments. The ratio of nitrate to ammonium is about one in rainfall, cloud water, throughfall and stemflow but the concentrations are much lower in rainfall (approximately 25 microM l(-1)) than in cloud water (approximately 300 microM l(-1)) while throughfall and stemflow are intermediate (approximately 80 microM l(-1)).

View Article and Find Full Text PDF

Soluble reactive phosphorus (SRP) data are presented for rainfall, cloud water, soil waters, stream waters and groundwaters at the Plynlimon catchments in mid Wales to examine the hydrochemical functioning of inorganic phosphorus for an acidic and acid sensitive area characteristic of much of the UK uplands. In general, stream water concentrations are low compared to lowland areas. Average concentrations of SRP in rainfall and cloud water (0.

View Article and Find Full Text PDF

This paper provides a foreword to a special edition of Science of the Total Environment concerned with land-ocean interaction from a UK perspective as linked to processes, functioning and environmental management. The volume structure is presented together with an outline of the nature of the individual papers. The areas covered are: (1) freshwater chemistry, (2) riverine sedimentology, (3) tidal river, estuarine and coastal chemistry, (4) estuarine and coastal sediments and (5) shelf-sea-ocean linkages.

View Article and Find Full Text PDF

The Hawaiian-Emperor hotspot track has a prominent bend, which has served as the basis for the theory that the Hawaiian hotspot, fixed in the deep mantle, traced a change in plate motion. However, paleomagnetic and radiometric age data from samples recovered by ocean drilling define an age-progressive paleolatitude history, indicating that the Emperor Seamount trend was principally formed by the rapid motion (over 40 millimeters per year) of the Hawaiian hotspot plume during Late Cretaceous to early-Tertiary times (81 to 47 million years ago). Evidence for motion of the Hawaiian plume affects models of mantle convection and plate tectonics, changing our understanding of terrestrial dynamics.

View Article and Find Full Text PDF

Utilizing agonist-stimulated GTPgammaS autoradiography, we analyzed the ability of preproorphanin FQ (ppOFQ) peptides to stimulate [35S]-GTPgammaS binding in adult rat brain. Orphanin FQ (OFQ) stimulated [35S]-GTPgammaS binding in a pattern similar to that described for [125I]-OFQ at the endogenous opioid receptor-like (ORL1) receptor. The ppOFQ peptides nocistatin and orphanin FQ2 (OFQ II(1-17)) had no effect, suggesting that they do not mediate their reported analgesic effects via a G(i/o)-coupled receptor (i.

View Article and Find Full Text PDF

Background: Bacterial colonisation of indwelling medical devices by coagulase-negative staphylococci is a prevalent risk in intensive-care units. Factors determining biofilm formation and progression to catheter- related infection are incompletely understood. We postulated that administration of inotropic agents via indwelling intravenous catheters may stimulate growth and formation of biofilms by Staphylococcus epidermidis.

View Article and Find Full Text PDF

Trauma is well recognized to result in the immediate and sustained release of stress-related neurochemicals such as the catecholamine norepinephrine. Past work has shown that in addition to their ability to function as neurotransmitters, catecholamines can also directly stimulate the growth of a number of pathogenic bacteria. The development of trauma-associated sepsis has often been linked to the ability of otherwise normal commensal bacteria to invade and penetrate the gut mucosal barrier.

View Article and Find Full Text PDF

A new method for the determination of hydraulic conductivity in individually perfused microvessels in vivo is described. A vessel is cannulated at both ends with glass micropipettes and the fluid filtration rate across the vessel wall measured from the velocities of red cells when the pressure in the micropipettes is balanced. Hydraulic conductivity measured using this double-cannulation method (2.

View Article and Find Full Text PDF