Publications by authors named "Ndung'u P"

Article Synopsis
  • The study focuses on complex Mycobacterium tuberculosis Lineage 3 (L3) strains, which are prevalent in regions with high tuberculosis rates, analyzing 2682 strains from 38 countries.
  • Researchers used advanced techniques like MIRU-VNTR genotyping and whole-genome sequencing to explore the genetic diversity and population structure of L3 strains across five continents.
  • Findings indicate that L3 strains originated in Southern Asia and later spread to North-East and East Africa, offering insights that could aid in the development of new treatments and vaccines for tuberculosis.
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"Ancestral" complex (MTBC) strains of Lineage 1 (L1, East African Indian) are a prominent tuberculosis (TB) cause in countries around the Indian Ocean. However, the pathobiology of L1 strains is insufficiently characterized. Here, we used whole genome sequencing (WGS) of 312 L1 strains from 43 countries to perform a characterization of the global L1 population structure and correlate this to the analysis of the synthesis of phenolic glycolipids (PGL) - known MTBC polyketide-derived virulence factors.

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Ruminants are central to the economic and nutritional life of much of sub-Saharan Africa, but cattle are now blamed for having a disproportionately large negative environmental impact through emissions of greenhouse gas (GHG). However, the mechanism underlying excessive emissions occurring only on some farms is imperfectly understood. Reliable estimates of emissions themselves are frequently lacking due to a paucity of reliable data.

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This dataset describes the performance of cattle in smallholder livestock systems of Bomet county in western Kenya. Information on live weight, milk production and quality, herd dynamics, and other production parameters were collected from field visits. Animals were weighed on scales; milk yield was recorded using a Mazzican® milk collection and transport vessel provided to each farm and milk was analyzed for butterfat content (%).

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Objective: This cross-sectional study conducted in Kibera, Kenya, sought to gain insights on relative microbial contamination levels of popular unprocessed food types, determine antimicrobial resistance (AMR) burden and the carriage of integrons that are essential elements for spreading antimicrobial resistance genes (ARG). Foods analysed consisted of cooked vegetables (kale, cabbage, and nightshades), boiled cereal foods (beans, rice, and Githeri, which is a mixture of beans and maize), meat, Omena fish (fried silver cyprinids), and Ugali (a product of simmered maize flour in boiled water).

Results: The analysis detected contamination levels exceeding 2×10 c.

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This paper reports on the preparation and modification of powdered maize tassels with polydiallyldimethylammonium chloride (polyDADMAC). The modified tassel were applied for the removal of phenolic compounds from water, through adsorption. The effect of contact time, sorbent dose, pH of the sample and the adsorption capacity were investigated at fixed temperature (25 °C).

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Introduction: In Kenya, which ranks thirteenth of 27 high tuberculosis burden countries, diagnosis is based on Ziehl-Neelsen staining alone and patients are treated without information on sensitivity patterns. This study aimed to determine resistance patterns of Mycobacterium tuberculosis isolated from pulmonary samples.

Methodology: Pulmonary tuberculosis patients in Nairobi were randomly sampled after informed consent and recruited into the study using a structured questionnaire.

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