Phylogenetic analysis of prospective M. bovis antigens with the aim of developing candidate vaccines for bovine tuberculosis.

Background: Bovine Tuberculosis is a respiratory disease caused by the pathogen Mycobacterium bovis (M. bovis) that infects cattle. Though rare, this disease can also affect humans, as well as domestic and wild animals, making it a serious concern.

Safety and Protective Efficacy of a Candidate Vector-Based Vaccine for Bovine Tuberculosis.

This study presents the results of a survey of the safety and protective efficacy of a candidate vector-based vaccine for bovine tuberculosis, using an influenza vector with the NS1 mutation and expressing M. bovis protective antigens ESAT-6 and TB10.4.

Characterization of the camel pox virus strain used in producing camel pox virus vaccine.

Background: The camel pox virus (CMLV) is a widespread infectious viral disease of camels. It is necessary to conduct research on new strains for the development of vaccines.

Aim: The research aims to characterize a novel strain isolated from the CMLV used to produce a CMLV vaccine.

Salmonella sheep abortion: Distribution, diagnosis, and control measures.

The purpose of the study is to identify and isolate the causative agent of Salmonella sheep abortion in the sheep breeding industry of the Republic of Kazakhstan. The study aims to provide a basis for the development and testing of vaccines against salmonella sheep abortion using the isolated epizootic strains of Salmonella abortus-ovis AN 9/2 and Salmonella abortus-ovis 372 as control strains for immunogenicity testing. Biomaterials and pathologic materials were investigated of 114 abortions, dead ewes, and newborn lambs using the bacteriological method with the diagnostic purpose from 2009 to 2019.

Prospects of bacteriophage collections in disinfectant applications.

Background And Aim: The search and development of disinfectants is promising worldwide. However, there are currently no international regulations governing the testing and registration of germicidal agents. Moreover, the number of safety requirements for disinfectants for human, animal, and environmental health has increased.

AK-2011 strain for the development of a vaccine against equine rhinopneumonitis.

Equine rhinopneumonitis is an acute, highly contagious disease found virtually worldwide. The purpose of the studies presented in this paper is to develop a technology for the manufacture of a cell-derived equine rhinopneumonitis vaccine, as well as to assess the safety and immunogenicity of the newly developed vaccine in laboratory animals model. The object of the studies was the AK-2011 strain isolated from the horses suffering from rhinopneumonitis during an outbreak of abortions.

Inactivated vaccine against Aujeszky's disease.

Background And Aim: The Aujeszky's disease, also known as Pseudorabies, remains one of the most problematic fulminant diseases in domestic animals, affecting the central nervous system. The study aimed to investigate the effect of an inactivated vaccine against Aujeszky's disease based on "Kordai" virus strain.

Materials And Methods: To test the inactivation of the "Kordai" strain (grown by the roller method in VNK-21/13 cell culture with an infectious titer of at least 7.

Impact of geographical factors on the spread of animal brucellosis in the Republic of Kazakhstan.

In Latin and Central America and in most Asian countries, brucellosis remains an insufficiently studied disease. This study aims to determine the national and regional incidence of brucellosis among cattle (cows) and small ruminants (sheep, goats) in the Republic of Kazakhstan, as well as to identify the effect of climatic and geographical factors on the incidence rates. Thematic maps were created in an open geographic information system QGIS version 2.

Phenotypic and genotypic characteristics of Brucella isolates from the Republic of Kazakhstan.

The purposes of this study were to determine phenotypic and genotypic characteristics of Brucella isolates from the Republic of Kazakhstan and to determine their biotype. The focus was laid on culture-morphological, biochemical, and biological properties of 59 Brucella isolates from primary cultures. Material was isolated from blood and tissue of serum-positive killed, dead diseased, or aborted domestic cattle from different regions of Kazakhstan where brucellosis is a common problem.

Reasons behind the epidemiological situation of brucellosis in the Republic of Kazakhstan.

Brucellosis is endemic in the Republic of Kazakhstan, particularly in agro-pastoral areas. The purpose of this research is to study the epidemiological situation of brucellosis in livestock recorded in the Republic of Kazakhstan, and to identify the reasons why anti-brucellosis measures were not effective. The research was performed on statistical data provided by the Republican Veterinary Laboratory (RVL), the Ministry of Agriculture of the Republic of Kazakhstan.

Diagnostics of tuberculosis and differentiation of nonspecific tuberculin reactions in animals.

Tuberculosis is a serious disease of humans and animals, caused by bacteria of the Mycobacterium genus. This leads to complications in the life of the sick person, and subsequently to death. The cattle, who have been diagnosed with this bacterium, are usually sent to the slaughter, with the result that their livestock is reduced.