Publications by authors named "Nazmul Hasan Rajib"
Article Synopsis
- - The study aimed to understand how long the protection from the typhoid conjugate vaccine (TCV) lasts by extending research from the TyVAC trial in Bangladesh to 5 years post-vaccination.
- - It found that children who received the TCV between 2018-2019 had a significantly higher risk of contracting typhoid compared to those vaccinated more recently, indicating that vaccine effectiveness declines over time.
- - The research showed an estimated vaccine effectiveness of only 50% in the 3-5 year period after vaccination, highlighting the need for further studies on booster doses to maintain immunity.
Article Synopsis
- Shigellosis is a major cause of diarrheal deaths in children under five, and there's currently no effective vaccine for Shigella infection, particularly in endemic areas.
- Researchers in Bangladesh studied the antibody responses in both young children and older individuals with confirmed shigellosis to understand the differences in immune response.
- Findings revealed that while higher antibody levels correlated with less severe disease, young children developed weaker and less effective immune responses compared to older individuals, which may hinder their ability to fight off Shigella effectively.
Article Synopsis
- - A cluster-randomized trial in Dhaka, Bangladesh, compared the Vi-TT vaccine with the JE vaccine as a control to evaluate immune responses in children.
- - A total of 1,500 children were selected in a 2:1 ratio (Vi-TT to JE) and blood samples were taken before vaccination and several times after, measuring anti-Vi-IgG response.
- - The results showed that a single dose of Vi-TT produced a strong and lasting antibody response for at least two years, which could help in understanding population protection against the disease in the future.
The burden of Salmonella enterica serotype Typhi (S. Typhi) shedding in stool and its contribution to transmission in endemic settings is unknown. During passive surveillance S.
View Article and Find Full Text PDFBackground: Typhoid fever remains a major cause of morbidity and mortality in low-income and middle-income countries. Vi-tetanus toxoid conjugate vaccine (Vi-TT) is recommended by WHO for implementation in high-burden countries, but there is little evidence about its ability to protect against clinical typhoid in such settings.
Methods: We did a participant-masked and observer-masked cluster-randomised trial preceded by a safety pilot phase in an urban endemic setting in Dhaka, Bangladesh.
Paratyphoid fever is one of the major causes of morbidity of febrile illnesses in endemic regions. We report a case of high-grade fever in an infant who was positive for serovar Paratyphi B (. Paratyphi B) both in blood and stool cultures.
View Article and Find Full Text PDF