Publications by authors named "Nazlı S Menemenli"
Article Synopsis
- * These nutrient-starved cancer cells showed increased amounts and sizes of lysosomes, which were primarily located near the nucleus, due to a boost in the protein Rab7a responsible for lysosomal trafficking.
- * The acidic environment of lysosomes in these cells can trap certain drugs like doxorubicin, contributing to drug resistance, but this resistance can be mitigated by using a lysosomal inhibitor, bafilomycin A1, which, along with 5-Fluorouracil, significantly reduced microtumor volume in tests.
During avian development, the chorioallantoic membrane (CAM) is generated around 4 days after fertilization following the fusion of the allantois and the chorion. The CAM develops rapidly over the next several days and gets heavily vascularized and therefore has been explored widely as a tool for the study of angiogenesis. Additionally, being immunodeficient, the CAM can be used for tumor growth of human origin and its metastasis.
View Article and Find Full Text PDFIntroduction: Nutrient restriction in cancer cells can activate a number of stress response pathways for cell survival. We aimed to determine mechanistically how nutrient depletion in colorectal cancer (CRC) cells leads to cellular adaptation.
Materials And Methods: Cell survival under nutrient depletion (ND) was evaluated by colony formation and in vivo tumor formation assays.