A Narrative Review on Various Oil Extraction Methods, Encapsulation Processes, Fatty Acid Profiles, Oxidative Stability, and Medicinal Properties of Black Seed ().

The current review investigates the effects of black seed () on human health, which is also used to encapsulate and oxidative stable in different food products. In recent decades, many extraction methods, such as cold pressing, supercritical fluid extraction, Soxhlet extraction, hydro distillation (HD) method, microwave-assisted extraction (MAE), ultrasound-assisted extraction, steam distillation, and accelerated solvent extraction (ASE) have been used to extract the oils from black seeds under optimal conditions. Black seed oil contains essential fatty acids, in which the major fatty acids are linoleic, oleic, and palmitic acids.

Butyrylation Meets Adipogenesis-Probed by a p300-Catalyzed Acylation-Specific Small Molecule Inhibitor: Implication in Anti-obesity Therapy.

The enzyme p300, besides having acetyltransferase activity, can also catalyze other acylation modifications, whose physiological implications are still being investigated. Here, we report that the level of histone butyrylation increases globally as well as locally in the promoters of pro-adipogenic genes during adipogenesis. To delineate the role of p300-catalyzed butyrylation from acetylation in adipogenesis, we identified a semisynthetic derivative (LTK-14A) of garcinol, which specifically inhibited histone butyrylation without affecting acetylation.

Autochthonous Gomont Driven Nickel (Ni) Phycoremediation from Cooking Oil Industrial Effluent.

Nickel (Ni) leftovers arise from both catalyst application interventions and Ni alloy piping of the cooking oil industry (COI) being wasted as pollutants of freshwater bodies via discharged effluent. The current study assessed one of the indigenously feasible Ni removal systems comprising autochthonous Gomont (AP)-driven Ni phycoremediation cells (NPCs). After screening AP for hyperaccumulation in the Ni spiked solution, AP was transferred to the NPCs.

Multiple checkpoints of protein clearance machinery are modulated by a common microRNA, miR-4813-3p, through its putative target genes: Studies employing transgenic C. elegans model.

In order to maintain cellular homeostasis and a healthy state, aberrant and aggregated proteins are to be recognized and rapidly cleared from cells. Parkinson's disease, known to be associated with multiple factors; presents with impaired clearance of aggregated alpha synuclein as a key factor. We endeavored to study microRNA molecules with potential role on regulating multiple checkpoints of protein quality control within cells.

Antibacterial and in vivo toxicological studies of BiO/CuO/GO nanocomposite synthesized via cost effective methods.

In this research work, BiO, BiO/GO and BiO/CuO/GO nanocomposites have been synthesized via an eco-friendly green synthesis technique, solgel route and co-precipitation method respectively for the assessment of antibacterial activity as well as in vivo toxicity. The XRD patterns confirm the formation of BiO, BiO/GO and BiO/CuO/GO nanocomposites showing monoclinic structures. Crystallite size and lattice strain are calculated by Scherrer equation, Scherrer plot and Willimson Hall plot methods.

Rise of syphilis surge amidst COVID-19 pandemic in the USA: A neglected concern.

Introduction: Syphilis is a treatable but highly contagious sexually transmitted disease (STI) that has a long history of infecting millions of people from diverse ethnicities and is mainly considered promiscuity. An uprise in syphilis cases is noted in the Coronavirus pandemic. This short communication discerns salient factors precipitating the syphilis upsurge, implications, current efforts, and recommendations.

Food-Grade Quercetin-Loaded Nanoemulsion Ameliorates Effects Associated with Parkinson's Disease and Cancer: Studies Employing a Transgenic Model and Human Cancer Cell Lines.

A nanosized food-grade quercetin-loaded nanoemulsion (QNE) system comprising capmul MCM NF (oil) and cremophor RH 40 (surfactant) was developed using a high-speed homogenization technique. The developed QNE was studied for its significant neuroprotective (anti-Parkinsonism) and cytotoxicity (anticancer) effects against Caenorhabditis elegans (C. elegans) strains and human cancer cells, respectively.

Isolation and genomic characterization of a novel Autographiviridae bacteriophage IME184 with lytic activity against Klebsiella pneumoniae.

Klebsiella pneumoniae, a multidrug resistant bacterium that causes nosocomial infections including septicemia, pneumonia etc. Bacteriophages are potential antimicrobial agents for the treatment of antibiotic resistant bacteria. In this study, a novel bacteriophage IME184, was isolated from hospital sewage against clinical multi-drug resistant Klebsiella pneumoniae.

Fad Diets: Facts and Fiction.

The global prevalence of obesity is alarmingly high and is impacting both developed and underdeveloped countries, beyond the borders of ethnicity, sex, and age. On the other hand, the global interest in dieting has increased, and people are obsessed with certain fad diets, assuming them as a magic bullet for their long-term problems. A fad diet is a popular dietary pattern known to be a quick fix for obesity.

Effects of microplastics on growth and metabolism of rice (Oryza sativa L.).

Present work studied the impact of different doses of polystyrene (PS) and polyvinyl chloride (PVC) microplastics (MPs) on rice plants (Oryza sativa L.). Seven different treatments of PS and PVC MPs viz.

Synthesis and antibacterial potential of Loranthus pulverulentus conjugated silver nanoparticles.

The green method is not only harmonious to our environment but saves time and is comparatively cheaper than other methods. The current study is aimed to synthesize the silver nanoparticles (AgNPs) using the green method by using the leaves of Loranthus pulverulentus Wall (LPW) which functioned as a reducing as well as capping agent. The synthesis of biogenic AgNPs was confirmed by UV-Vis spectroscopy (UV-Vis.

COVID-19 pandemic: Direct effects on the medical education in Pakistan.

• To date, the medical education literature has focused on strategies for high-income countries to optimize online education. • Low- and middle-income countries' students face additional challenges in providing virtual education. • The main challenges LMIC students face are frequent internet and electricity outages and limited technology skills.

Management of Idiopathic Pyoderma Gangrenosum With Azathioprine As the Primary Adjunct in an Asian Man: A Case Report.

Pyoderma gangrenosum (PG) is a very rare, non-infectious, progressive inflammatory condition falling under the umbrella of neutrophilic dermatoses. It is an ulcerative condition with a wide variety of cutaneous manifestations and multiple clinical variants (classic ulcerative, pustular, bullous, and superficial granulomatous). Additionally, owing to similar patterns of mucocutaneous ulceration, it has certain overlaps with other neutrophilic diseases frequently observed in clinical practice.

The effect of combined loading on the behavior of micropiled rafts installed with inclined condition.

One of the major disadvantages of micropiles is their low lateral stiffness and flexural rigidity due to the small diameter. This limitation can be handled in current practice, by installing the micropile with inclined condition or providing a steel casing. Additional steel casings will increase the lateral load capacity of micropiles but increase the project cost as well.

Identification of homozygous missense variant in SIX5 gene underlying recessive nonsyndromic hearing impairment.

Hearing impairment (HI) is a heterogeneous condition that affects many individuals globally with different age groups. HI is a genetically and phenotypically heterogeneous disorder. Over the last several years, many genes/loci causing rare autosomal recessive and dominant forms of hearing impairments have been identified, involved in various aspects of ear development.

Fecal Microbiota Transplant in Recurrent Clostridium Difficile Infections: A Systematic Review.

Fecal Microbiota Transplantation (FMT) is the process of transferring the fecal microbiome from a healthy donor to an individual with repeated multiple episodes of Clostridium difficile infection. It is also known as stool transplant. Fecal microbiota transplant is effective and safe in various studies, the approval from the Food and Drug Administration (FDA) remains pending.

Design for Additive Manufacturing and Investigation of Surface-Based Lattice Structures for Buckling Properties Using Experimental and Finite Element Methods.

Additive Manufacturing (AM) is rapidly evolving due to its unlimited design freedom to fabricate complex and intricate light-weight geometries with the use of lattice structure that have potential applications including construction, aerospace and biomedical applications, where mechanical properties are the prime focus. Buckling instability in lattice structures is one of the main failure mechanisms that can lead to major failure in structural applications that are subjected to compressive loads, but it has yet to be fully explored. This study aims to investigate the effect of surface-based lattice structure topologies and structured column height on the critical buckling load of lattice structured columns.

Pathophysiology and rehabilitation management of exercise intolerance in COVID-19 patients.

Objective: This review aimed to explore the pathophysiology and rehabilitation management of exercise intolerance in COVID-19 patients.

Methods: We reviewed articles published in 2019-2021 using PubMed, Google Scholar, and CINAHL databases as an electronic database. Data obtained were pathophysiology and rehabilitation management of exercise intolerance in COVID-19 survivors.

Biodiesel Production from Alkali-Catalyzed Transesterification of Seed Oil and Optimization of Process Conditions.

Biodiesel is considered a sustainable alternative to petro-diesel owing to several favorable characteristics. However, higher production costs, primarily due to the use of costly edible oils as raw materials, are a chief impediment to its pecuniary feasibility. Exploring non-edible oils as raw material for biodiesel is an attractive strategy that would address the economic constraints associated with biodiesel production.

Role of composted tannery solid waste and its autochthonous microbes in enhancing phytoextraction of toxic metals and stress abatement in sunflower.

The excessive concentration of multiple heavy metals in the tannery solid waste (TSW) needs integrated process solutions for its decontamination. This study is aimed at deriving TSW compost and autochthonous microbe synergies for improving phytoextraction potential of sunflower. In-vessel composting of TSW was carried out by using fruit waste as an inoculum to achieve the optimized conditions.

Purification, characterization, and determination of biological activities of water-soluble polysaccharides from Mahonia bealei.

Mahonia bealei is one of the important members of the genus Mahonia and Traditional Chinese Medicine (TCM). Several compounds isolated from this plant have exhibited useful biological activities. Polysaccharides, an important biomacromolecule have been underexplored in case of M.

Interactive effect of amino acids balanced at ideal lysine ratio and exogenous protease supplemented to low CP diet on growth performance, carcass traits, gut morphology, and serum metabolites in broiler chicken.

This study evaluated the effect of amino acids balanced at a specific lysine ratio with exogenous protease supplementation and reduced CP levels in the broiler diet. In total, 480 straight-run broiler chicks (Ross-308) were used for the study. A completely randomized design in the factorial arrangement was applied, with 4 treatments of 6 replicates with 20 birds each.

Advances in antibubble formation and potential applications.

Antibubbles are unusual physical objects consisting of a liquid core(s) surrounded by a thin air film/shell while in a bulk liquid. Antibubbles carry two air-liquid interfaces, i.e.