Modelling assisted phytoextraction of heavy metals from tannery origin leachate.

The toxic tannery solid waste leachate (TSWL) containing heavy metals is generated after the percolation of rainwater in openly dumped tannery solid waste (TSW) which poses a serious threat to the surroundings by leaching down and bioaccumulation. For its management, the phytoextraction potential of Pistia stratiotes L. and Spirodela polyrhiza L.

Evaluating the antioxidant, anti-inflammatory, and neuroprotective potential of fruiting body and mycelium extracts from edible yellow morel (Morchella esculenta L. Pers.).

Scope: This study aimed to assess the antioxidant, anti-inflammatory, and acetylcholinesterase activities of fruiting bodies (FB) and mycelium (M) extracts of Morchella esculenta L. collected from various regions of Pakistan. The samples included Skardu fruiting body (SKFB) and mycelia Skardu (SKM), Malam Jaba fruiting body (MJFB) and Malam Jaba mycelia (MJM), Krair Mansehra fruiting body (KMFB) and Krair Mansehra mycelia (KMM), and Thandiani fruiting body (TFB) and Thandiani mycelia (TM).

Damping Optimization and Energy Absorption of Mechanical Metamaterials for Enhanced Vibration Control Applications: A Critical Review.

Metamaterials are pushing the limits of traditional materials and are fascinating frontiers in scientific innovation. Mechanical metamaterials (MMs) are a category of metamaterials that display properties and performances that cannot be realized in conventional materials. Exploring the mechanical properties and various aspects of vibration and damping control is becoming a crucial research area.

Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels in .

Mutations in highly conserved genes encoding components of the electron transport chain (ETC) provide valuable insights into the mechanisms of oxidative stress and mitochondrial ROS (mtROS) in a wide range of diseases, including cancer, neurodegenerative disorders, and aging. This review explores the structure and function of the ETC in the context of its role in mtROS generation and regulation, emphasizing its dual roles in cellular damage and signaling. Using as a model organism, we discuss how ETC mutations manifest as developmental abnormalities, lifespan alterations, and changes in mtROS levels.

Preparation and characterization of chitosan and polyvinyl alcohol active film incorporated with Syzygium guineense plant extract as active packaging materials.

The advancement of active packaging for food conservation has attracted considerable interest over time. In the present study, we aims to create and examine active films composed of chitosan (CS), poly(vinyl alcohol) (PVA), and syzygium guineense plant extract (SYZ) for potential use in food preservation. We examined the impact of ethanol extracts from the SYZ plant on the films' tensile strength, physical, antibacterial, and anti-oxidant properties.

A New Hope for the Patients of Non-Alcoholic Steatohepatitis: FDA Gives Green Signal for Resmetirom Use.

Background And Aims: Non-Alcoholic Steatohepatitis (NASH), a severe form of Non-Alcoholic Fatty Liver Disease (NAFLD), is characterized by inflammation and fibrosis in the liver, often progressing to cirrhosis and hepatocellular carcinoma. Despite its rising prevalence and significant disease burden, effective pharmacological treatments have been limited to lifestyle modifications and surgical interventions. Recently, resmetirom, a thyroid hormone receptor-β agonist, received FDA approval for treating NASH, offering new hope to patients.

Retraction notice to "Degradation of cefadroxil drug by newly designed solar light responsive alcoholic template-based lanthanum ferrite nanoparticles" [Environ. Res. 231P3 (2023) 116241].

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/locate/withdrawalpolicy).

Assessing the Impact of Early Nutritional Intervention on Pediatric Celiac Disease Management: A Prospective Cohort Study.

Background: Celiac disease is a chronic autoimmune condition requiring lifelong adherence to a gluten-free diet, particularly in children, to prevent nutritional deficiencies and developmental delays.

Objective: The objective of study was to evaluate the effects of early nutritional intervention on the management and health outcomes of children diagnosed with celiac disease.

Methodology: A prospective, longitudinal cohort study was conducted over two years (July 2019-July 2021).

The Incidence of Early Postoperative Complications Following Modified Radical Mastectomy in Breast Cancer Patients.

Introduction Breast cancer is considered the most common malignant tumor in women, and incidence rates have risen progressively over the last decades. Modified radical mastectomy (MRM) is an effective treatment option. This research sought to establish the frequency, causes, and distribution of postoperative complications that are associated with MRM in the Pakistani population suffering from breast cancer.

Study protocol for a Prospective Observational study of Safety Threats and Adverse events in Trauma (PrO-STAT): a pilot study at a level-1 trauma centre in Canada.

Introduction: Traumatic injuries are a significant public health concern globally, resulting in substantial mortality, hospitalisation and healthcare burden. Despite the establishment of specialised trauma centres, there remains considerable variability in trauma-care practices and outcomes, particularly in the initial phase of trauma resuscitation in the trauma bay. This stage is prone to preventable errors leading to adverse events (AEs) that can impact patient outcomes.

Endophytic fungi: nature's solution for antimicrobial resistance and sustainable agriculture.

The growing threat of antimicrobial resistance (AMR) has underlined the need for a sustained supply of novel antimicrobial agents. Endophyte microorganism that reside within plant tissues as symbionts have been the source of potential antimicrobial substances. However, many novel and potent antimicrobials are yet to be discovered from these endophytes.

Assessment of azithromycin-induced toxicity in : Effects on morphology, behavior, and lipid metabolism.

Antibiotics are indispensable in modern healthcare, playing a critical role in mitigating bacterial infections. Azithromycin is used to fight upper respiratory tract infections, however has potential toxic effects that remain inadequately understood. In our present study, azithromycin exposure to led to significant physiological and behavioral change, with pronounced effects observed at the studied concentration.

Optimal Antithrombotic Regimen After Cryptogenic Stroke: A Systematic Review and Network Meta-Analysis.

Although several antithrombotic strategies have been investigated for the management of cryptogenic strokes, ie, ischemic strokes without known etiologies, an optimal antithrombotic strategy for cryptogenic strokes is unknown. We aim to assess oral antithrombotic agents' comparative efficacy and safety after cryptogenic stroke to identify an optimal treatment.A systematic review and meta-analysis synthesizing evidence from randomized controlled trials (RCTs) obtained from PubMed, Embase Cochrane, Scopus, and Web of Science until February 2024.

Advancing microbiota therapeutics: the role of synthetic biology in engineering microbial communities for precision medicine.

Over recent years, studies on microbiota research and synthetic biology have explored novel approaches microbial manipulation for therapeutic purposes. However, fragmented information is available on this aspect with key insights scattered across various disciplines such as molecular biology, genetics, bioengineering, and medicine. This review aims to the transformative potential of synthetic biology in advancing microbiome research and therapies, with significant implications for healthcare, agriculture, and environmental sustainability.

A novel approach in cancer diagnosis: integrating holography microscopic medical imaging and deep learning techniques-challenges and future trends.

Medical imaging is pivotal in early disease diagnosis, providing essential insights that enable timely and accurate detection of health anomalies. Traditional imaging techniques, such as Magnetic Resonance Imaging (MRI), Computer Tomography (CT), ultrasound, and Positron Emission Tomography (PET), offer vital insights into three-dimensional structures but frequently fall short of delivering a comprehensive and detailed anatomical analysis, capturing only amplitude details. Three-dimensional holography microscopic medical imaging provides a promising solution by capturing the amplitude (brightness) and phase (structural information) details of biological structures.

L-lysine and surfactant-assisted synthesis of NiCo bimetal oxides for electrochemical water splitting.

In the present study, bimetallic oxides comprising nickel (Ni) and cobalt (Co) were synthesized using a facile hydrothermal method in the presence of CTAB and L-lysine. Their efficacy in catalyzing hydrogen production under alkaline conditions was assessed. Structural, vibrational, and morphological characteristics were analyzed utilizing X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM) techniques.

Recent Trends in Development of Novel Therapeutics for Modulation of 14-3-3 Protein-Protein Interactions in Diseases.

14-3-3s constitute a group of proteins belonging to the phosphoserine/phosphothreonine family that are involved in the regulation of several physiological pathways by interacting with several client proteins. All the eukaryotic cells are known to possess 14-3-3 isoforms. In addition, 14-3-3s isolated from different eukaryotic cells share high sequence homology with each other.

IRON DEFICIENCY WITHOUT ANAEMIA IN COPD PATIENTS: ASSESSING EXERCISE CAPACITY AND EXACERBATION FREQUENCY.

Background: Chronic Obstructive Pulmonary Disease (COPD) is a global health challenge with significant morbidity and mortality. Iron deficiency, including non-anaemic iron deficiency (NAID), has been identified as a potential comorbid in COPD, affecting patient outcomes and disease severity. This study aimed to investigate the prevalence and impact of iron deficiency on the severity and clinical outcomes in COPD patients.

By-product distribution and cytotoxicity assessment of ZnO-assisted photocatalytic degradation of reactive blue 250 dye.

This research examined the effectiveness and feasibility of utilizing ultraviolet (UV) assisted photo-catalysis to treat wastewater effluents from textile production containing reactive blue 250 (RB 250) dye. Molecular oxygen and active species like O , HO , HO and OH play crucial roles in the degradation process. Additionally, the degradation of dyes is influenced by several factors, including dye concentration, duration of UV irradiation, pH levels, concentration of HO, and the catalyst.

Retrospective Assessment of Post-Transurethral Resection of the Prostate Complications in Benign Prostatic Hyperplasia Patients: Impact of Acute Urinary Retention.

Background Benign prostatic hyperplasia (BPH) is the most common urological condition affecting older men, leading to lower urinary tract symptoms (LUTS) and complications such as acute urinary retention (AUR), which can significantly impact quality of life. This study aims at comparing the postoperative outcomes and complication rates of monopolar transurethral resection of the prostate (TURP) in BPH patients with and without AUR. By examining the differences in postoperative outcomes, the study seeks to highlight the impact of AUR on complications such as UTIs, prolonged catheterization, and extended hospital stays, and assess the potential clinical implications for improving treatment strategies in these patients.

Comprehensive Analysis of Thyroidectomy-Related Complications: A Single-Center Perspective.

Background Thyroid surgeries have become so common that they are performed for both benign and malignant conditions of the thyroid. However, hypoparathyroidism and recurrent laryngeal nerve (RLN) injury may turn out to be a nightmare, complicating the surgical outcome. This study will, therefore, attempt to assess the complications related to different types of thyroid surgeries in order to identify the risk factors involved.

Hysterotomy for retained placenta in suspected angular pregnancy.

Background: Angular pregnancy is a rare event and is a commonly missed diagnosis in the antepartum period. Data regarding the optimal mode of delivery and management of the placenta are limited.

Case Description: A patient in her 30s, gravida 3, para 1 presented at 37 weeks with severe range blood pressure and was admitted for induction of labour due to preeclampsia.

Depression detection in dementia: A diagnostic accuracy systematic review and meta analysis update.

Background: Depression is common in persons with dementia and is often under-detected and under-treated. It is critical to understand which available tools accurately detect depression in the context of dementia.

Methods: We updated our systematic review completed in 2015.

Ethical considerations in surgical research conducted in African LMICs: a comprehensive narrative review.

Introduction: Surgical research has revolutionized healthcare by improving the efficacy, safety, and efficiency of surgical interventions. This research has the potential to significantly impact healthcare delivery in Africa, where surgical diseases pose a major public health burden. Studies suggest surgery alone could reduce the global disease burden by 11%, with a substantial portion stemming from conditions prevalent in sub-Saharan Africa like traumatic injuries, childbirth complications, and surgical infections.