Publications by authors named "Nazim Abdel Aati"
Article Synopsis
- - The study investigates potential diagnostic biomarkers for Autism Spectrum Disorder (ASD) by analyzing cytokine levels in plasma samples from children aged 2-4 in Qatar, comparing those with ASD (n = 100) to controls (n = 60).
- - Researchers identified elevated levels of IFN-γ and FGF-2 as significant indicators for ASD, while lower levels of eotaxin and HGF were linked to a reduced likelihood of having the disorder; a combination of these four cytokines showed promising diagnostic accuracy.
- - The findings suggest that specific cytokine profiles could effectively differentiate children with ASD from typically developing peers, highlighting their potential as biomarkers for the disorder.
Article Synopsis
- Autism spectrum disorder (ASD) prevalence in Qatar is around 1.1%, but genetic research in the region is limited; the BARAKA-Qatar Study aims to create a biorepository for ASD families to facilitate future research.
- * Whole-genome sequencing (WGS) analysis of 100 families revealed potentially pathogenic variants in 27% of them, with a notable contribution from dominant and homozygous variants, particularly in consanguineous families.
- * The study also identified 28 new candidate genes related to ASD, emphasizing the importance of including under-represented populations in genetic research to understand the disorder better.
Prevalence and correlates of autism spectrum disorder in Qatar: a national study.
J Child Psychol Psychiatry
December 2019
Background: Few epidemiological data on autism spectrum disorders (ASD) exist for Arabic countries. We conducted the first survey of ASD in Qatar, a population with high consanguinity level.
Methods: This cross-sectional survey was conducted from 2015 to 2018 in Qatar school-age children (N = 176,960) from national and immigrant families.