Publications by authors named "Nazeer Ahmad Khan"
Article Synopsis
- The study examines the role of β-glucosidase in hyperglycemia and non-alcoholic fatty liver disease, leading to liver cancer (HepG2).
- Researchers synthesized phthalimide and phthalamic acid analogs, which showed potential as inhibitors of β-glucosidase, utilizing in silico and in vitro techniques for analysis.
- Results indicated that some synthesized compounds had superior inhibitory effects compared to standard treatments, and further testing demonstrated their cytotoxicity against HepG2 cancer cell lines.
Small molecules with nitrogen-containing scaffolds have gained much attention due to their biological importance in the development of new anticancer agents. The present paper reports the synthesis of a library of new dihydropyridine and pyridine analogs with diverse pharmacophores. All compounds were tested against the human tissue nonspecific alkaline phosphatase (-TNAP) enzyme.
View Article and Find Full Text PDFSynthesis, evaluation of thymidine phosphorylase and angiogenic inhibitory potential of ciprofloxacin analogues: Repositioning of ciprofloxacin from antibiotic to future anticancer drugs.
Bioorg Chem
July 2020
Over expression of thymidine phosphorylase (TP) in various human tumors compared to normal healthy tissue is associated with progression of cancer and proliferation. The 2-deoxy-d-ribose is the final product of thymidine phosphorylase (TP) catalyzed reaction. Both TP and 2-deoxy-d-ribose are known to promote unwanted angiogenesis in cancerous cells.
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