Publications by authors named "Nazarov T"

Article Synopsis
  • The study investigates how developmental changes affect peroxisome activity, focusing on gene expression patterns in specific metabolic pathways across developmental stages in plants.
  • It finds that photorespiration is more prominent in adult leaves compared to juvenile stages, with additional pathways related to reactive oxygen species (ROS) and polyamine catabolism becoming more active as leaves mature.
  • Key genes, including those related to GABA synthesis, are upregulated in older seedlings, suggesting that GABA plays a role in regulating peroxisome fission during leaf differentiation.
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Article Synopsis
  • The study investigates how autophagy, a process for recycling cellular components, may have been inadvertently favored in wheat breeding for better yield in dry environments.
  • Researchers tested this by examining responses of wheat strains to heat and drought, focusing on three key proteins associated with autophagy: ATG7, ATG8, and NBR1.
  • Results showed that certain wheat genotypes displayed increased autophagic activity and better yields, while others showed less autophagy, highlighting that different stress-resilient mechanisms may also play a role in crop performance.
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Rust fungi cause significant damage to wheat production worldwide. In order to mitigate disease impact and improve food security via durable resistance, it is important to understand the molecular basis of host-pathogen interactions. Despite a long history of research and high agricultural importance, still little is known about the interactions between the stripe rust fungus and wheat host on the gene expression level.

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Article Synopsis
  • - Organelles play crucial roles in cellular metabolism and structure, while their life cycles encompass stages like formation, maturation, and decay, leading to biochemical diversity even among similar-looking organelles.
  • - The "organellome" refers to the total collection of organelles in a biological system at a specific time, whose balance is maintained through complex interactions and influenced by energy needs and environmental factors.
  • - The study of organellomics focuses on understanding the structural diversity and abundance of organelles, which is key for exploring plant adaptability and responses to environmental changes, thus adding a crucial time dimension to existing biological research.
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Drought and heat stress substantially impact plant growth and productivity. When subjected to drought or heat stress, plants exhibit reduction in growth resulting in yield losses. The occurrence of these two stresses together intensifies their negative effects.

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Drought resiliency strategies combine developmental, physiological, cellular, and molecular mechanisms. Here, we compare drought responses in two resilient spring wheat ( genotypes: a well-studied drought-resilient Drysdale and a resilient genotype from the US Pacific North-West Hollis. While both genotypes utilize higher water use efficiency through the reduction of stomatal conductance, other mechanisms differ.

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Although peroxisomes play an essential role in viral pathogenesis, and viruses are known to change peroxisome morphology, the role of genotype in the peroxisomal response to viruses remains poorly understood. Here, we analyzed the impact of wheat streak mosaic virus (WSMV) on the peroxisome proliferation in the context of pathogen response, redox homeostasis, and yield in two wheat cultivars, Patras and Pamir, in the field trials. We observed greater virus content and yield losses in Pamir than in Patras.

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Aim: To obtain the information about functional state of kidneys in patients with urolithiasis before and after treatment, as well as to study the damaging effect of different types of energy used for fragmentation of high-density stones.

Materials And Methods: A total of 105 patients aged from 25 to 62 years with high-density stones were undergone to lithotripsy. In Group 1 (n=38), Group 2 (n=32) and Group 3 (n=35) contact laser lithotripsy, contact ultrasound lithotripsy and extracorporeal shock-wave lithotripsy was used, respectively.

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A total of 115 children aged 13-17 years (mean age 15.77 +/- 1.89 years, 98 boys and 17 girls) with essential arterial hypertension (EAH) were examined.

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Efficacy of tadenan was studied in combined treatment of 30 patients suffering from chronic prostatitis complicated by sterility. Positive results were achieved. Tadenan efficacy manifested with attenuation of the symptoms, improvement of spermogram, quality of life, prostatic structure, circulation, increased maximal urine flow rate.

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Overall 62 patients coral calculi underwent percutaneous nephrolithotripsy and distant shock-wave lithotripsy (DSWL). Percutaneous nephrolithotripsy as monotherapy was effective at 47 (75.8%) patients.

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The diagnosis and treatment of 120 patients with urolithiasis were made. The following examinations were made: the study of immune status and lipid peroxidation, detection of selective proteinuria, leukocyte migration inhibition reaction with autoantigens obtained from the tissues of the renopelvic segment providing additional information about renal parenchyma and immune system. The patients were divided into two groups: 70 patients of the study group received pre-, intra- and postoperative preventive pharmacotherapy, while 50 patients of the control group received standard therapy.

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