Publications by authors named "Nazar M Smereczanski"
The impact of cadmium (Cd) on the function and structure of the kidney and the potential protective effect of an extract from L. berries were investigated in a rat model of low- and moderate-level environmental exposure to this heavy metal (1 and 5 mg Cd/kg feed for up to 24 months). The sensitive biomarkers of Cd-induced damage to the kidney tubules (N-acetyl-β-D-glucosaminidase (NAG), alkaline phosphatase (ALP), β2-microglobulin (β2-MG), and kidney injury molecule-1 (KIM-1) in the urine), clinically relevant early markers of glomerular damage (albumin in the urine and creatinine clearance), and other markers of the general functional status of this organ (urea, uric acid, and total protein in the serum and/or urine) and Cd concentration in the urine, were evaluated.
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- * It reviews research showing that even low levels of Cd found in industrialized countries can lead to kidney damage and chronic kidney disease (CKD).
- * The study identifies specific concentration thresholds in blood and urine that indicate potential harm, suggesting that current environmental exposure levels pose a risk to kidney health.
The impact of a polyphenol-rich 0.1% aqueous extract from L. berries (AE) on the body status of manganese (Mn) and the activity of this essential element-dependent mitochondrial superoxide dismutase (MnSOD) during treatment with cadmium (Cd) was investigated in a rat model of low-level and moderate environmental human exposure to this xenobiotic (1 and 5 mg Cd/kg diet, respectively, for 3-24 months).
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- A study on rats investigated whether increasing zinc (Zn) intake could protect against brain damage caused by cadmium (Cd) exposure.
- Cadmium exposure led to a decrease in antioxidant defenses and an increase in oxidative stress, causing damage to lipids and proteins in the brain.
- Supplementing with zinc reduced cadmium accumulation in brain tissue and helped maintain antioxidant balance, suggesting that higher zinc intake may offer protective benefits against oxidative stress related to cadmium exposure.