Benth. Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats through the Antioxidant Pathways.

Methods: In this experimental study, 35 male Wistar rats (120-180 g) were divided into five groups ( = 7) as follows: intratracheal instillation of bleomycin (BLM, 7.5 IU/kg) was administered to group II. The third and fourth groups received BLM plus hydroalcoholic extract (SPHE) (300 mg/kg/day, gavage).

Protective and therapeutic effects of ethanolic extract of (watercress) and vitamin E against bleomycin-induced pulmonary fibrosis in rats.

Background And Purpose: Pulmonary fibrosis is a chronic disease of the lungs caused by inflammation, species of reactive oxygen, and immune defects. Antioxidant properties of has been reported in some studies. Therefore, the objective of the current study was to evaluate the effect of ethanolic extract of (EENO) on bleomycin (BLM)-induced lung fibrosis in rats.

The hydroalcoholic extract of watercress attenuates protein oxidation, oxidative stress, and liver damage after bile duct ligation in rats.

Cholestatic liver disease is recognized by extreme collagen formation and deposition, which is mediated by free radicals. The aim of the current study was to investigate the probable hepatoprotective effects of hydroalcoholic extract of watercress (WC) against oxidative stress and liver injury in bile duct ligation (BDL)- induced cholestatic rats. A total of 32 male Wistar rats were divided into four groups; sham control (SC), BDL, SC + hydroalcoholic extract of WC and BDL + hydroalcoholic extract of WC.

Cytotoxic effect of methanolic extract, alkaloid and terpenoid fractions of against HT-29 cell line.

Benth (Lamiaceae) is used in traditional medicine to treat a variety of diseases. Despite some reports on the antitumor effects of some species of this genus, anticancer activity of has not been yet reported. Here, we examined the cytotoxic effect and cell death mechanisms of methanolic extract of and its alkaloid and terpenoid fractions on the HT-29 colorectal cell line.

Hepatoprotective effect of Stachys pilifera ethanol extract in carbon tetrachloride-induce hepatotoxicity in rats.

Context: Stachys pilifera Benth (Lamiaceae) has long been used to treat infectious diseases, respiratory and rheumatoid disorders in Iranian folk medicine. Antitumor and antioxidant activity of the plant have been reported.

Objective: The study was designed to assess the hepatoprotective activity of ethanol extract of Stachys pilifera in carbon tetrachloride (CCl)-induced hepatotoxicity in rats.

Melatonin Increases Oligodendrocyte Differentiation in Cultured Neural Stem Cells.

Neural stem cell (NSC) culture is a remarkable tool to investigate the potential therapeutic benefits of drugs in neurological diseases. The purpose of this study was to determine the effect of melatonin on proliferation and differentiation of NSCs in vitro. NSCs were isolated and expanded from mouse embryonic E14 cortex, and the effect of various concentrations of melatonin (0.