Anti-oncogenic perspectives of spices/herbs: A comprehensive review.

Contemporary nutrition regime has focused the attention of the researchers on phytochemicals enriched spices to mitigate various oncological threats. Numerous chemopreventive strategies against malignancy have been developed considering the anticancer perspectives of allied nutraceutical constituents. Current evidences have proven an inverse association of spices with that of oncological incidences.

Effects of preoperative single dose Etoricoxib on postoperative pain and sleep after lumbar diskectomy: prospective randomized double blind controlled study.

Background: Etoricoxib, a selective Cox-2 inhibitor has been found to be effective in the management of acute pain. This study evaluates the effect of preoperative use of oral Etoricoxib on post operative pain relief and sleep in patients undergoing single level diskectomy.

Methods: In this prospective, randomized, controlled study, forty four patient (ASA 1 & 2, age 18-60 years) scheduled to undergo single level lumber diskectomy were given either placebo (control group) or Etoricoxib 120 mg orally one hour before surgery.

Investigation of piperidine derivatives in ex vivo models of pain and platelet aggregation.

Piperidine derivatives are known to exhibit analgesic activities and are likely to possess the ability to block the effects of prostaglandins through inhibition of downstream signaling pathways. The present study investigated the activity of five derivatives (PD2-6) of 4-(4'-bromophenyl)-4-piperidinol (PD1), against pain and platelet aggregation mediated by the release of prostaglandins and thromboxane A2, respectively. The results showed that compound PD1 and its two phenacyl derivatives PD3 and PD5 exhibited a highly significant analgesic effect (p < 0.

AB-QTL analysis reveals new alleles associated to proline accumulation and leaf wilting under drought stress conditions in barley (Hordeum vulgare L.).

Background: Land plants have evolved several measures to maintain their life against abiotic stresses. The accumulation of proline is the most generalized response of plants under drought, heat or salt stress conditions. It is known as an osmoprotectant which also acts as an instant source of energy during drought recovery process.

Enhancement in the germination, growth and yield of okra (Abelmoschus esculentus) using pre-sowing magnetic treatment of seeds.

The effect of pre-sowing magnetic treatments was investigated on germination, growth and yield of okra (Abelmoschus esculentus cv. Sapz pari). The dry okra seeds were exposed to sinusoidal magnetic field induced by an electromagnet.

Thrombophilia investigation in Pakistani women with recurrent pregnancy loss.

Aim: The aim of the study was to identify thrombophilic defects in women with a history of recurrent miscarriage.

Methods: This was a case-control study in which the cases were women who had undergone spontaneous recurrent pregnancy losses and the controls were women in matched reproductive age groups without any history of miscarriage or pregnancy loss. Both groups of women were identified from our department's high-risk and gynecological outpatient clinics.

Frequency of factor VIII (FVIII) inhibitor in haemophilia A.

Objective: To determine the frequency of factor VIII specific inhibitors in haemophilia A.

Study Design: Cross-sectional study.

Place And Duration Of Study: National Institute of Blood Disease and Bone Marrow Transplantation, Karachi, from August 2007 to March 2009.

JAK2V617F mutation in chronic myeloid leukemia predicts early disease progression.

Objective: To determine the association of JAK2V617F mutation along with BCR-ABL translocation or Philadelphia chromosome in chronic myeloid leukemia with early disease progression to advanced stages (accelerated phase or blast crisis) and poor outcome.

Study Design: Case series.

Place And Duration Of Study: National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, from February 2008 to August 2009.

Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae.

Bioassay-guided isolation studies on the extracts of yellow flowers of Tagetes patula L. against the Heterodera zeae were carried out to identify phytochemicals lethal to this economically important cyst nematode. In vitro investigation of a polar extract and fractions showing activity led to the isolation of phenolic compounds (flavonoids and phenolic acids).

Transfusion transmitted infections in patients with hemophilia of Karachi, Pakistan.

The aim of the study was to assess the prevalence of HCV, HBV, and HIV infections among the patients with hemophilia. Patients with Hemophilia A and B were evaluated who visited hospital for factor replacement therapy. The viral markers tested in these patients included anti-HCV-Ab, HBsAg, and anti-HIV-Ab.

Bioassay-guided isolation of antioxidant agents with analgesic properties from flowers of Tagetes patula.

Context: Tagetes patula L. is one of the French marigold group of the Asteraceae family. It is recognized in folklore for its medicinal and pesticidal properties.

Congenital bleeding disorders in Karachi, Pakistan.

Objective: To determine the frequency of inherited bleeding disorders, its complications, and treatment modalities available for its treatment.

Design: Cross-sectional study.

Patients And Methods: Patients with a history of bleeding tendency were tested for confirmation of the diagnosis.

Clinical features and types of von Willebrand disease in Karachi.

This study was conducted on patients with a history of congenital bleeding disorders or with suspected bleeding tendencies. Laboratory analysis revealed Von Willebrand disease (VWD) in 68 (21.3%) of 318 participants with male to female ratio of 0.

Bleeding disorders in the tribe: result of consanguineous in breeding.

Objective: To determine the frequency and clinical features of bleeding disorders in the tribe as a result of consanguineous marriages.

Design: Cross Sectional Study

Introduction: Countries in which consanguinity is a normal practice, these rare autosomal recessive disorders run in close families and tribes. Here we describe a family, living in village Ali Murad Chandio, District Badin, labeled as haemophilia.

Safety of daily albuterol in infants with a history of bronchospasm: a multi-center placebo controlled trial.

Introduction: Inhaled short-acting bronchodilators are recommended for the quick relief of bronchospasm symptoms in children including those less than five years of age. However, limited safety data is available in this young population.

Methods: Safety data were analyzed from a randomized, double-blind, parallel group, placebo-controlled multicenter, study evaluating albuterol HFA 90microg or 180microg versus placebo three times a day for 4 weeks using a valved holding chamber, Aerochamber Plus and facemask in children birth View Article and Find Full Text PDF

Pharmacokinetic interaction of ciprofloxacin with diclofenac: a single-dose, two-period crossover study in healthy adult volunteers.

Background And Objective: Ciprofloxacin is a broad-spectrum, synthetic antibacterial used for the treatment of various bacterial infections. In multidrug therapy, ciprofloxacin is commonly prescribed with analgesics for the management of infection, pain and inflammation. The objective of this study was to evaluate the pharmacokinetic properties of ciprofloxacin tablets with concurrent administration of diclofenac tablets in healthy adult human volunteers.

Studies on the atropisomerism of Fe(II) 2,6-bis(N-arylimino)pyridine complexes.

NMR spectra of free 2,6-bis(N-arylimino)pyridine (PDI) ligands displaying different substituents at the ortho and ortho' positions of the two N-aryl rings indicate that they can exist in syn (meso) and anti (chiral) configurations. These interconvert in solution at room temperature, via rotation of the aryl group. The corresponding paramagnetic FeX(2)(PDI) complexes exhibit the same kind of isomerism, a property that is thought to be important for their activity as alpha-olefin polymerization catalysts.

Conformational analysis (geometry optimization) of nucleosidic antitumor antibiotic showdomycin by Arguslab 4 software.

Showdomycin is a naturally maleimide antitumor antibiotic of the C-nucleoside, it inhibits the nucleic acid synthesis in bacteria. Conformational analysis and geometry optimization of showdomycin was performed according to the Hartree-Fock (HF) calculation method by ArgusLab 4.0.

Separation of a diiminopyridine iron(II) complex into rac- and meso- diastereoisomers provides evidence for a dual stereoregulation mechanism in propene polymerization.

Separation of a diiminopyridine iron(II) complex into its rac- and meso- diastereoisomers provides for first time the opportunity of observing the enantiomorphic site control competing with the chain-end control mechanism in a non-metallocene catalyst system.

Arteriovenous thrombosis in chronic renal failure patients receiving renal replacement therapy.

Objective: To determine the frequency of thrombotic complications and to identify factors associated with arteriovenous thrombosis in patients of chronic renal failure receiving renal replacement therapy.

Study Design: A descriptive study.

Place And Duration Of Study: The study was carried out at Sindh Institute of Urology and Transplantation (SIUT), Karachi, from May 2003 to December 2003.

AB-QTL analysis in winter wheat: II. Genetic analysis of seedling and field resistance against leaf rust in a wheat advanced backcross population.

The present study aimed to localize exotic quantitative trait locus (QTL) alleles for the improvement of leaf rust (P. triticina) resistance in an advanced backcross (AB) population, B22, which is derived from a cross between the winter wheat cultivar Batis (Triticum aestivum) and the synthetic wheat accession Syn022L. The latter was developed from hybridization of T.