Bone and Joint Involvement in Beta Thalassemic Patients: A Cross-sectional Study.

Purpose: There is paucity of guidelines with inadequate data available about the extent and prevention of bone and joint disease in beta-thalassemic patients in Indian population. This study aims to determine bone and joint involvement in beta-thalassemic patients. It evaluates serum biochemical parameters of bone formation and resorption and correlates with the symptomatology in these patients.

Breaking the silence: The role of extracellular vesicles in unraveling the diagnosis and treatment of endometriosis.

Cell-to-cell communication is believed to be facilitated by membrane-bound vesicles called extracellular vesicles (EVs), which are released by cells. Protein, lipids, and nucleic acids are major cargo of EVs and are transported in these vesicles. Depending on the parent and recipient cell types, they can affect a wide variety of biological processes in the tissues to which they are delivered.

Development of interprofessional educational module for understanding the musculoskeletal basis of sports injury.

Context: Interprofessional education (IPE) is crucial in promoting a better understanding of collaborative practices within the healthcare system. Unfortunately, healthcare professionals are still working in isolation. To address this issue, a study was conducted to develop a module-based teaching and learning activity focusing on sports injuries and to promote IPE.

Age changes in Corpus Callosum among Indian cadaver specimens: a normative study.

Background: During neurosurgeries like corpus callosotomy (palliative procedure performed in case of intractable seizures) surgical separation of corpus callosum is required. In order to perform the surgical separation of corpus callosum, one needs to have complete knowledge about anatomy and morphometry of corpus callosum. The current study was carried out in order to establish the normative data about morphometry of corpus callosum across various age groups.

Racial Disparities in Immediate Breast Reconstruction after Mastectomy: A Systematic Review and Meta-Analysis.

In the past few decades, there has been a gradual increase in breast reconstruction post mastectomy; however, there exists a conflict about whether race has an influence on reconstruction rates. We conducted an electronic search from MEDLINE and Cochrane CENTRAL from their inception to September 2022. Primary outcome was disparity in rates of Immediate Breast Reconstruction (IBR) in racial minorities.

Dual-Wide Multi-Band (DWMB) four-port flexible MIMO antenna for on-body multiple wireless applications including high diversity performance.

The single-input-single-output technology experiences loss of data in the communication channel due to the receiving antenna undergoing fading of the signal impinged on it. Today's need is faster data transfer with multiple applications in the single antenna with multiple-identical radiating elements, leading to multiple-input-multiple-outputDWMB (MIMODWMB) technology. The MIMODWMB configuration with multi-band capability is the objective of the proposed work with applications ranging between microwave-millimeterWave bands.

Silent Damage by Micro-aspirations: Untangling the Connection of Gastroesophageal Reflux Disease (GERD) and Achalasia With Interstitial Lung Disease.

Gastroesophageal reflux disease (GERD) frequently triggers respiratory conditions such as asthma and pneumonia. Inflammation occurs as a result of aspirated material, leading to symptoms such as cough, sputum production, chest discomfort from the involvement of the lower respiratory tract, and voice hoarseness owing to the involvement of the larynx. Repeated exposure to irritants can lead to fibrosis in the lungs.

Enhancing DDoS detection in SDIoT through effective feature selection with SMOTE-ENN.

Internet of things (IoT) facilitates a variety of heterogeneous devices to be enabled with network connectivity via various network architectures to gather and exchange real-time information. On the other hand, the rise of IoT creates Distributed Denial of Services (DDoS) like security threats. The recent advancement of Software Defined-Internet of Things (SDIoT) architecture can provide better security solutions compared to the conventional networking approaches.

Impact of COVID-19 pandemic on the mental health status among general masses: An in-deep analysis of the worst "hitters" of COVID-19 pandemic.

Background: A plethora of studies have reported the adverse psychiatric outcomes among the general masses during the COVID-19 pandemic; however, not much data is available in relation to the Indian population from this perspective. The aim of the present study was to investigate the impact of the COVID-19 pandemic on the mental health status among the general masses in the Indian population.

Materials And Methods: The present study was planned in a cross-sectional study design between July 2020 and October 2021 in which a well-structured questionnaire, consisting of questions assessing the sociodemographic profile, while, also, specific questions related to the stress and anxiety-related variables, was used.

Patterns of care and outcomes for hepatocellular carcinoma and pancreatic cancer based on rurality of patient's residence in a rural midwestern state.

Background: Although advancements in surgical planning and multidisciplinary care have improved the survival of patients with hepatopancreatic cancers in recent years, the impact of the rurality of patient residence on care received and survival is not well known. We aimed to assess the association between the rurality of a patient's residence and cancer-specific survival outcomes among patients with hepatocellular carcinoma (HCC) and pancreatic cancer (PC) in Iowa, hypothesizing that patients in rural areas would experience lower survival.

Methods: Adult patients diagnosed with HCC or PC between 2010 and 2020 were identified using the Iowa Cancer Registry.

Comparative Evaluation of Clinical Outcome Including Neurosensory Deficit and Pain Score Variables Using Rigid Internal Fixation with Three-Dimensional Miniplate Internal Fixation in Simultaneous Angle and Contralateral Body/Parasymphysis Fractures of the Mandible: A Prospective, Randomized Controlled Study.

 There have been numerous advancements in the strategies used for treating mandibular fractures in the present times, while open reduction and internal fixation is still accepted as the most preferred treatment option for such fractures despite numerous drawbacks. The aim of the present prospective, randomized controlled study was to evaluate the clinical outcome including neurosensory deficit and pain score variables in mandibular fractures that were treated using rigid internal fixation with three-dimensional (3D) miniplate internal fixation.  For the present study, a total of 20 patients of either sex in an age range of 18 to 55 years with simultaneous angle and contralateral body/parasymphysis fractures of the mandible were included, while the clinical outcome was compared in relation to the two groups wherein different treatment options were used including using rigid internal fixation in one as against 3D miniplate internal fixation in the other.

COVID-19-Associated Sepsis: Potential Role of Phytochemicals as Functional Foods and Nutraceuticals.

The acute manifestations of coronavirus disease 2019 (COVID-19) exhibit the hallmarks of sepsis-associated complications that reflect multiple organ failure. The inflammatory cytokine storm accompanied by an imbalance in the pro-inflammatory and anti-inflammatory host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to severe and critical septic shock. The sepsis signature in severely afflicted COVID-19 patients includes cellular reprogramming and organ dysfunction that leads to high mortality rates, emphasizing the importance of improved clinical care and advanced therapeutic interventions for sepsis associated with COVID-19.

Traumatic Dental Injuries and their Association with Demographics and Other Predisposing Risk Factors in School Children Aged between 8-13 Years: A Descriptive, Cross-Sectional Study.

Background: Traumatic dental injuries are most commonly seen in school age children. This not only affects physical, but, also, the psychological and social well-being of a child. The aim of the present study was to assess the prevalence of traumatic dental injuries in school children aged between 8 and 13 years and their association with the demographics and other predisposing risk factors.

Dependability of Electrode to Modiolus Distance in Patients Specific Electrode Selection: A Cadaveric Model Study.

Objective: This study aims to discern the disparities in the electrode-to-modiolus distance (EMD) between cochleostomy and round window approaches when performed sequentially in the same temporal bone. Additionally, the study seeks to identify the cochlear metrics that contribute to these differences.

Methodology: A cross-sectional study was conducted, involving the sequential insertion of a 12-electrode array through both round window and cochleostomy approaches in cadaveric temporal bones.

Densitometry of STR-PAGE for donor chimerism in acute leukemia's: A simple method for routine use.

Objective: To evaluate a PCR based method of polyacrylamide gel electrophoresis of short tandem repeats and its quantification for detecting donor chimerism after haematopoietic stem cell transplantation in acute leukaemias.

Methods: The descriptive study was conducted at Genetic Resource Centre (GRC) Lab Rawalpindi from Feb 2018 - Nov 2020. A total of twenty patients with acute leukaemias having undergone HSCT were selected and assessed for the analysis of chimerism status.

The Association Between Low Preoperative Phosphate Levels and Postliver Surgery Outcomes-A Single Center Experience.

Introduction: Previous research has demonstrated the impact of postoperative phosphate levels on liver regeneration and outcomes after liver resection surgeries, a potential predictor for regenerative success and liver failure. However, little is known about the association between low preoperative serum phosphate levels and outcomes in liver resections.

Methods: We performed a retrospective analysis of liver resections performed at our institution.

Clinical and CSF single-cell profiling of post-COVID-19 cognitive impairment.

Natural history and mechanisms for persistent cognitive symptoms ("brain fog") following acute and often mild COVID-19 are unknown. In a large prospective cohort of people who underwent testing a median of 9 months after acute COVID-19 in the New York City/New Jersey area, we found that cognitive dysfunction is common; is not influenced by mood, fatigue, or sleepiness; and is correlated with MRI changes in very few people. In a subgroup that underwent cerebrospinal fluid analysis, there are no changes related to Alzheimer's disease or neurodegeneration.

Evaluation of association between center colorectal neuroendocrine neoplasm volume and survival among patients with colorectal neuroendocrine carcinoma.

Background: Although correlation between center volume and survival has been reported for several complex cancers, it remains unknown if this is true for colorectal neuroendocrine carcinomas (CRNECs). We hypothesized that higher center annual volume of colorectal neuroendocrine neoplasm resections would be associated with overall survival (OS) for patients with CRNECs.

Methods: Patients in the National Cancer Database diagnosed with stages I-III CRNEC between 2006 and 2018 and who underwent surgical resection were identified.

Comparison of depth of electrode insertion between cochleostomy and round window approach: a cadaveric study.

Introduction: Round window approach and cochleostomy approach can have different depth of electrode insertion during cochlear implantation which itself can alter the audiological outcomes in cochlear implant.

Objective: The current study was conducted to determine the difference in the depth of electrode insertion via cochleostomy and round widow approach when done serially in same temporal bone.

Methodology: This is a cross-sectional study conducted in the Department of Otorhinolaryngology in conjunction with Department of Anatomy and Department of Diagnostic and Interventional Radiology over a period of 1 year.

Canine retraction and anchorage loss using self-ligating and conventional brackets with sliding mechanics: A split-mouth clinical study.

Objective: Appliance biocompatibility, orthodontic treatment efficiency and patient convenience are the major issues confronting contemporary orthodontic practice. Very few studies have been published till date regarding the efficiency of self-ligating brackets as against conventional brackets. Hence, the present study was planned to compare the rate of canine retraction between self-ligating and conventional brackets and to determine the amount of anchorage loss during canine retraction.

Comparison of shear bond strength of composite resin, compomer, and resin-modified glass-ionomer cements in primary teeth: An study.

Objective: The contemporary esthetic restorative materials such as composite resin and glass-ionomer cements and their modifications have all been developed keeping in mind the requirements of permanent teeth. There have been plenty of studies that have focused on the characteristics of these materials in relation to permanent teeth with a relative dearth of such studies as regard to the primary teeth. The present study was undertaken to compare and evaluate the shear bond strength of composite resin, compomer, and resin-modified glass-ionomer cements in primary teeth.

Comparative evaluation of impact strength of mechanically modified heat polymerized polymethyl methacrylate (PMMA) resin with addition of 0.5, 1, 2 wt% of silver nanoparticles (AgNPs): An in-vitro study.

Objective: Polymethyl methacrylate (PMMA) is one of the most widely used denture base material because of favorable esthetics and desirable characteristics such as easy handling. Acrylic resins, although, have some inherent disadvantages such as relatively poor physical and mechanical properties. The objective of the present study was to evaluate and compare the impact strength of unmodified and modified heat cure PMMA-based denture base material with addition of different concentrations of silver nanoparticles (AgNPs) (0.

Comparative evaluation of variations in torque expression in maxillary incisor and canine using different bracket prescriptions placed at different crown levels by finite element (FE) method: An analysis.

Objective: While using preadjusted brackets, the position of the bracket on the crown is one of the deciding factors that determine the tooth's final tip, torque, height, and rotation. The final tooth position is not optimal if the bracket is placed incorrectly or if the varying crown morphology does not correspond with the bracket design. The present study was conducted to evaluate and compare the variations in torque expression in maxillary incisor and canine using different bracket prescriptions placed at different crown levels by finite element method.

Morphometric Comparison of Endoscopic Endonasal Transpterygoid and Precaruncular Contralateral Medial Transorbital Approaches to Sphenoid Sinus Lateral Recess.

Background And Objectives: The endoscopic endonasal transpterygoid approach (TPA), minimally invasive compared with the sublabial transmaxillary and transcranial approaches, still accounts for morbidity in benign lateral recess of sphenoid sinus (LRSS) pathologies. Others have suggested an alternative route to the LRSS, the endoscopic contralateral medial transorbital approach (cMTO). However, no quantitative evidence exists to support the clinical application of this approach.