The impact of antiarrhythmics on human pulmonary arteries: Ex vivo characterization.

Background And Aim: The safety and efficacy of the antiarrhythmic agents, amiodarone, and digoxin, in patients with pulmonary hypertension (PH), is not described well in the literature, although their use is common practice. Our study aims to investigate the effect of these drugs on pulmonary arteries (PA) which may have implications for their use in patients with PH.

Methods: Human PAs were obtained from consenting patients undergoing lobectomies.