Publications by authors named "Nayera A Moneib"
Article Synopsis
- Prolonged use of antibiotics for acne treatment has led to increased resistance, prompting research into natural antimicrobials as alternatives.
- Five essential oils were tested, with thyme essential oil showing the strongest antimicrobial and anti-inflammatory properties, making it the most effective among them.
- Thyme oil's nanoemulsion demonstrated both the ability to disrupt bacterial cell membranes and reduce inflammation in acne animal models, indicating its potential as a natural treatment option.
Article Synopsis
- The study focuses on how microorganisms, particularly the model organism K-12 MG1655, adapt to stressful conditions (like heat, cold, oxidative, nitrosative stress, and antibiotic treatment) by altering their gene expression.
- A systems biology approach was used to analyze existing transcriptomic data, revealing that energy conservation leads to the downregulation of certain metabolic pathways while genes related to survival and stress response are upregulated.
- The research highlights 15 genes with unknown functions that are notably upregulated during stress, suggesting they could be important for developing strategies to combat antibiotic resistance.
Background: Bacterial ghosts are the evacuated bacterial cellular membranes from most of the genetic and protein contents which preserved their surface characters. Recently, bacterial ghosts exploited for different biomedical applications, for instance, vaccination. The purpose of this study is to measure the immunogenic protective response of bacterial ghosts of Salmonella Typhimurium in animals and to allow future testing this response in humans.
View Article and Find Full Text PDFIntroduction: Toxin-antitoxin (TA) systems are widespread among bacteria, archaea and fungi. They are classified into six types (I-VI) and have recently been proposed as novel drug targets.
Objectives: This study aimed to screen the pathogen , known for its alarming antimicrobial resistance, for TA systems and identified a CptBA-like type IV TA, one of the least characterized systems.
Cell- based targeted delivery is recently gain attention as a promising platform for delivery of anticancer drug in selective and efficient manner. As a new biotechnology platform, bacterial ghosts (BGs) have novel biomedical application as targeted drug delivery system (TDDS). In the current work, Salmonellas' BGs was utilized for the first time as hepatocellular cancer (HCC) targeted delivery system.
View Article and Find Full Text PDFBacterial ghosts (BGs) can be prepared by both genetic and chemical means. Genetic method include using lysis gene . Chemical method include incubation with numerous agents for a short time at their minimum inhibitory or minimum growth concentrations (MIC or MGC).
View Article and Find Full Text PDFBacterial adhesion to urinary catheter was evaluated by measuring the light emitted from a recombinant bioluminescent glycocalyx producer Escherichia coli strain. Generation of the bioluminescent strain was carried out by transforming the bacterial cells with pUCP18-GFP plasmid that contains a green fluorescence gene. Light emission measurement was closely correlated with the number of the adherent cells, giving a detectable signal from 1.
View Article and Find Full Text PDF