Publications by authors named "Nayeon Bak"
Article Synopsis
- Coronaviruses need host proteases, like KLK5, to activate their spike proteins, enabling them to enter host cells and release their genetic material.
- KLK5 is particularly effective among the KLK family, as it activates spike proteins of several human betacoronaviruses, including SARS-CoV-2, while other proteases like KLK12 and KLK13 have more specialized roles.
- The study suggests that targeting KLK5 with compounds such as ursolic acid could be a potential treatment to inhibit coronavirus replication and reduce inflammation in infected individuals.
Structure-based drug design (SBDD) has gained popularity owing to its ability to develop more potent drugs compared to conventional drug-discovery methods. The success of SBDD relies heavily on obtaining the three-dimensional structures of drug targets. X-ray crystallography is the primary method used for solving structures and aiding the SBDD workflow; however, it is not suitable for all targets.
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