Screening of Synthetic Heterocyclic Compounds as Antiplatelet Drugs.

Background: Antiplatelet drugs represent the keystone in the treatment and prevention of diseases of ischemic origin, including coronary artery disease. The current palette of drugs represents efficient modalities in most cases, but their effect can be limited in certain situations or associated with specific side effects. In this study, representatives of compounds selected from series having scaffolds with known or potential antiplatelet activity were tested.

Series of Functionalized 5-(2-Arylimidazo[1,2-]pyridin-3-yl)pyrimidine-2,4(1,3)-diones: A Water-Mediated Three-Component Catalyst-Free Protocol Revisited.

A water-mediated and catalyst-free practical method for the synthesis of a new series of pharmaceutically interesting functionalized 5-(2-arylimidazo[1,2-]pyridin-3-yl)pyrimidine-2,4(1,3)-diones has been accomplished based on a one-pot multicomponent reaction between arylglyoxal monohydrates, 2-aminopyridines/2-aminopyrimidine, and barbituric/,-dimethylbarbituric acids under reflux conditions. The salient features of this protocol are avoidance of any additive/catalyst and toxic organic solvents, use of water as reaction medium, clean reaction profiles, operational simplicity, ease of product isolation/purification without the aid of tedious column chromatography, good to excellent yields, and high atom-economy and low -factor.

Target prioritization of novel substituted 5-aryl-2-oxo-/thioxo-2,3-dihydro-1-benzo[6,7]chromeno[2,3-]pyrimidine-4,6,11(5)-triones as anticancer agents using approach.

Cancer is a multi-origin collection of diseases attributed by abnormal and uncontrolled cell growth spread from origin to other parts of body eventually leading to death. After decades of research, anticancer drug therapy is still very much limited to inhibiting growth and controlling the spread of tumour cells. Finding novel molecular targets and drug candidates using assimilation of experimental and computational approaches is among the recent strategies adopted by researchers to speed up the anticancer drug discovery process.

Catalyst-Free One-Pot Three-Component Synthesis of Diversely Substituted 5-Aryl-2-oxo-/thioxo-2,3-dihydro-1-benzo[6,7]chromeno[2,3-]pyrimidine-4,6,11(5)-triones Under Ambient Conditions.

A simple, catalyst-free, straightforward, and highly efficient one-pot synthesis of pharmaceutically interesting diverse kind of a new series of functionalized 5-aryl-2-oxo-/thioxo-2,3-dihydro-1-benzo[6,7]chromeno[2,3-]pyrimidine-4,6,11(5)-triones () and substituted 5,5'-(1,4-phenylene)bis(2-oxo-/thioxo-2,3-dihydro-1-benzo[6,7]chromeno[2,3-]pyrimidine-4,6,11(5)-trione) derivatives () has been developed based on a three-component reaction between barbituric acid/,-dimethylbarbituric acid/2-thiobarbituric acid (), aromatic aldehydes (), and 2-hydroxy-1,4-naphthoquinone () in aqueous ethanol at room temperature (25-30 °C). The salient features of this protocol are mild reaction conditions, use of no catalyst, no need of column chromatographic purification, excellent yields, high atom economy, eco-friendliness, easy isolation of products, and reusability of reaction media.