Publications by authors named "Nayara T D de Azevedo"
Article Synopsis
- During protein synthesis, fully made protein subunits interact with newly forming partner proteins, which is key for efficient assembly but not fully understood.
- Researchers investigated specific structural features in nucleoporins that might aid this co-translational assembly and found new interactions.
- Their findings revealed that certain motifs enable selective interactions with proteins that often participate in multiple complexes, suggesting a complex regulatory dynamic in how proteins assemble during synthesis.
MicroRNAs (miRNAs) are small non-coding RNA molecules, with sizes ranging from 18 to 25 nucleotides, which are key players in gene expression regulation. These molecules play an important role in fine-tuning early vertebrate embryo development. However, there are scarce publicly available miRNA datasets from non-mammal embryos, such as the chicken (Gallus gallus), which is a classical model system to study vertebrate embryogenesis.
View Article and Find Full Text PDFThe spike protein (S) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is required for cell entry and is the primary focus for vaccine development. In this study, we combined cryo-electron tomography, subtomogram averaging, and molecular dynamics simulations to structurally analyze S in situ. Compared with the recombinant S, the viral S was more heavily glycosylated and occurred mostly in the closed prefusion conformation.
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