Publications by authors named "Nayanne Gama Teixeira Dantas"
Background: In recent decades, Mycobacterium tuberculosis with the RD genotype, frequently isolated from tuberculosis patients in Rio de Janeiro, has become part of the Latin American - Mediterranean (LAM) family and has been associated with multidrug-resistant tuberculosis (MDR-TB). The aim of this study was to investigate the frequency of M. tuberculosis RD in the state of Minas Gerais, Brazil, and its relationship with MDR-TB.
View Article and Find Full Text PDFArticle Synopsis
- - The study focused on genotyping M. tuberculosis strains from new TB cases in Minas Gerais to better understand how the disease spreads.
- - It compared two genotyping methods: RFLP-IS6110 and MIRU-VNTR, finding that both had high discriminatory power and detected considerable similarity among the strains.
- - Results indicated that the RFLP technique showed no signs of recent transmission, while it provided a better epidemiological relationship compared to MIRU-VNTR when identifying clusters of infection.
Correlation between the BACTEC MGIT 960 culture system with Genotype MTBDRplus and TB-SPRINT in multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil.
Mem Inst Oswaldo Cruz
November 2017
Background: The accurate detection of multidrug-resistant tuberculosis (MDR-TB) is critical for the application of appropriate patient treatment and prevention of transmission of drug-resistant Mycobacterium tuberculosis isolates. The goal of this study was to evaluate the correlation between phenotypic and molecular techniques for drug-resistant tuberculosis diagnostics. Molecular techniques used were the line probe assay genotype MTBDRplus and the recently described tuberculosis-spoligo-rifampin-isoniazid typing (TB-SPRINT) bead-based assay.
View Article and Find Full Text PDFBackground: We aimed to characterize the genetic diversity of drug-resistant Mycobacterium tuberculosis (MTb) clinical isolates and investigate the molecular epidemiology of multidrug-resistant (MDR) tuberculosis from Minas Gerais State, Brazil.
Methods: One hundred and four MTb clinical isolates were assessed by IS6110-RFLP, 24-locus mycobacterial interspersed repetitive units variable-number tandem repeats (MIRU-VNTR), TB-SPRINT (simultaneous spoligotyping and rifampicin-isoniazid drug-resistance mutation analysis) and 3R-SNP-typing (analysis of single-nucleotide polymorphisms in the genes involved in replication, recombination and repair functions).
Results: Fifty-seven different IS6110-RFLP patterns were found, among which 50 had unique patterns and 17 were grouped into seven clusters.