Putative DNA modification methylase DR_C0020 of Deinococcus radiodurans is an atypical SAM dependent C-5 cytosine DNA methylase.

Background: Control of cellular processes by epigenetic modification of cytosine in DNA is widespread among living organisms, but, is hitherto unknown in the extremely radioresistant microbe D. radiodurans.

Methods: C-5 methyl cytosines (mC) were detected by immuno-blotting with mC-specific antibody.

Epigenetic modulation upon exposure of lung fibroblasts to TiO and ZnO nanoparticles: alterations in DNA methylation.

Titanium dioxide (TiO) and zinc oxide (ZnO) nanoparticles (NPs) are promising candidates for numerous applications in consumer products. This will lead to increased human exposure, thus posing a threat to human health. Both these types of NPs have been studied for their cell toxicity, immunotoxicity, and genotoxicity.