[Immunotherapy in oncogynaecology].

Immune checkpoint inhibitors have deeply changed treatment paradigm of many tumor types, notably by providing long-term remissions, even in the metastatic setting. These immunotherapies aim to restore T-cells activity against tumour cells, in particular via the inhibition of PD1/PD-L1 interaction. As for lung or renal carcinomas, and melanomas, the management of endometrial and uterine cervical cancers has been disrupted by PD1/PD-L1 inhibitors efficacy.

The impact of sarcopenia on survival and treatment tolerance in patients with head and neck cancer treated with chemoradiotherapy.

Background: Sarcopenia appears to be a negative prognostic factor for poor survival outcomes and worse treatment tolerance in patients with head-and-neck squamous cell carcinoma (HNSCC). We evaluated sarcopenia's impact on overall survival (OS), disease-free survival (DFS) and chemo-radiation tolerance in patients with head-and-neck cancer (HNC) treated with chemoradiotherapy (CRT) from a monocentric observational study.

Methods: We identified patients with HNC treated by CRT between 2009 and 2018 with pretreatment imaging using positron emission tomography-computed tomography scans (PET/CT).

Outcomes of Patients With Active Cancer and COVID-19 in the Intensive-Care Unit: A Multicenter Ambispective Study.

Background: Several studies report an increased susceptibility to SARS-CoV-2 infection in cancer patients. However, data in the intensive care unit (ICU) are scarce.

Research Question: We aimed to investigate the association between active cancer and mortality among patients requiring organ support in the ICU.

Aluminum and iron can be deposited in the calcified matrix of bone exostoses.

Exostosis (or osteochondroma) is the most common benign bone tumor encountered in children and adults. Exostoses may occur as solitary or multiple tumors (in the autosomal syndromes of hereditary multiple exostoses). Exostoses are composed of cortical and medullary bone covered by an overlying hyaline cartilage cap.

Acute vasospastic attack after extradural block in a patient with Raynaud's disease.

Raynaud's disease is an episodic and debilitating disease of the circulation to the fingers and toes. This case report describes an acute exacerbation of Raynaud's disease in a patient undergoing surgery with epidural anesthesia. This potentially hazardous complication has not been previously reported.

Postoperative pain. Expectation and experience after coronary artery bypass grafting.

A study of 43 patients undergoing coronary artery bypass grafting was conducted in order to compare pre-operative expectation of pain severity and duration to actual postoperative experience. As judged by linear visual analogue scores, patients expected more pain than they experienced (p = 0.0359).

Extradural air as a cause of paraplegia following lumbar analgesia.

A 52-year-old woman with chronic back pain presented for lumbar extradural analgesia. The 'loss of resistance to air' technique was used to locate the extradural space. Prolonged paraesthesia and paresis of left leg occurred following the procedure.

[Diaphyseal fractures of the lower extremity].

The authors present a series of 26 cases of ipsilateral fractures of the shafts of the femur and tibia treated by internal fixation. Twenty have been followed up for more than 2 years. Thirteen healed without incident and achieved excellent function.

[Treatment of chondrosarcoma of the tibia by cryosurgery. Apropos of 2 cases].

Two grade II central tibial chondrosarcomata of have been treated by extensive curettage and cryotherapy as described by Marcove. No recurrences or metastases were present after a follow-up of six and eight-and-a-half years respectively. A review of the treatment of these tumours was made and the advantages and disadvantages of liquid nitrogen considered.

The omnicardiogram Study of a proposed method for detecting coronary heart disease in an asymptomatic population.

A proprietary, commercial technique has been proposed by its inventor as a noninvasive method of detecting subtle electrocardiogram abnormalities, not apparent by conventional means. To study the ability of the omnicardiogram to detect latent coronary heart disease in an asymptomatic population, 200 normal electrocardiograms from the Framingham Study cohort were analyzed by this technique. One-half of these consisted of the last normal electrocardiogram prior to development of clinical coronary heart disease.