FcγRIIIa receptor polymorphism influences NK cell mediated ADCC activity against HIV.

Background: HIV-specific Antibody Dependent Cell Cytotoxicity (ADCC) has shown to be important in HIV control and resistance. The ADCC is mediated primarily by natural killer cell activated through the binding of FcγRIIIa receptor to the Fc portion of antibody bound to the antigen expressed on the infected cells. However, no data is available on the influence of the polymorphism in FcγRIIIa receptor on HIV-specific ADCC response.

Polymorphisms in Toll-Like Receptors (TLRs)-7 and Genes in Indian Population with Progressive and Nonprogressive HIV-1 Infection.

The polymorphisms in Toll-like receptor () and 9 genes are shown to influence HIV-1 infection. We studied HIV-1-infected Indian individuals for presence and association of and gene polymorphism with different disease outcomes. Genomic DNA from 65 HIV-infected individuals (35 long-term nonprogressors and 30 progressors) and 89 uninfected healthy donors was isolated, amplified, and sequenced for the reported polymorphisms in [Gln11Leu (A/T); rs179008] and (1635A/G; rs352140) genes.

HECT Domain and RCC1-Like Domain-Containing Protein 5 (HERC-5) Gene Polymorphisms in HIV-1-Infected Individuals: A Study from India.

HECT domain and RCC1-like domain-containing protein 5 (HERC-5) is one of the novel host restriction factors that is known to inhibit HIV release in vitro. Polymorphisms in other host restriction factors have been associated with HIV infection and disease progression. However, no report is available on the HERC-5 polymorphism in HIV-infected individuals.

Utility of the point of care CD4 analyzer, PIMA, to enumerate CD4 counts in the field settings in India.

Background: In resource limited settings non-availability of CD4 count facility at the site could adversely affect the ART roll out programme. Point of care CD4 enumerating equipments can make the CD4 count available at the site of care and improve the patients' management considerably. This study is aimed at determining the utility of a Point of Care PIMA CD4 analyzer (Alere, Germany) in the field settings in India.