Efficacy of short-synthetic antifungal peptides on pathogenic Aspergillus flavus.

The efficacies of three short synthetic antifungal peptides were tested for their inhibitory action on pathogenic fungi, Aspergillus flavus. The sequences of the short synthetic peptides are PPD1- FRLHF, 66-10-FRLKFH, 77-3- FRLKFHF, respectively. These test peptides inhibited fungal growth and showed a membranolytic activity.

Molecular docking and molecular dynamics simulation identify a novel Radicicol derivative that predicts exclusive binding to Topoisomerase VIB.

harbors a unique type II topoisomerase, Topoisomerase VIB (TopoVIB), expressed specifically at the actively replicating stage of the parasite. An earlier study showed that Radicicol inhibits the decatenation activity of TopoVIB and thereby arrests the parasites at the schizont stage. Radicicol targets a unique ATP-binding fold called the Bergerat fold, which is also present in the N-terminal domain of the heat shock protein 90 (Hsp90).

Function annotation of peptides generated from the non-coding regions of D. melanogaster genome.

De novo emergence of genes is the most fundamental form of genetic diversity that is attracting the attention of the scientific community. Identification of short open reading frames (sORFs) from the non-coding regions of different genomes has been leading this thought recently. The coding potential of these newly identified sORFs have been investigated through experimental and computational approaches in recent studies.

Predicting stable functional peptides from the intergenic space of .

Expression of synthetic proteins from intergenic regions of and their functional association was recently demonstrated (Dhar et al. in J Biol Eng 3:2, 2009. doi:10.

In silico study of peptide inhibitors against BACE 1.

Peptides are increasingly used as inhibitors of various disease specific targets. Several naturally occurring and synthetically developed peptides are undergoing clinical trials. Our work explores the possibility of reusing the non-expressing DNA sequences to predict potential drug-target specific peptides.