Coexistence of Monoclonal Gammopathy and Hemolysis in Chronic Lymphocytic Leukemia: Unveiling a Rare Case.

In B-cell malignancies, there is a periodic presence of monoclonal gammopathies. In a notable multitude of cases with chronic lymphocytic leukemia (CLL), a cluster of antigen-inciting B-cells sometimes shows the presence of monoclonal gammopathy and autoimmune hemolysis simultaneously. The detection of monoclonal proteins or light chains in urine and/or serum is significantly increased in cases of CLL and can be identified using highly sensitive laboratory methods, such as serum protein electrophoresis.