Personalized mechanistic models for exercise, meal and insulin interventions in children and adolescents with type 1 diabetes.

Personalized mechanistic models involving exercise, meal and insulin interventions for type 1 diabetic children and adolescents are not commonly seen in the literature. Patient specific variations in blood glucose homeostasis and adverse effects of exercise-induced hypoglycemia emphasize the need for personalized models. Hence, a modified mechanistic model for exercise, meal and insulin interventions is proposed and tailored as personalized models for 34 type 1 diabetic children and adolescents.