The Preparation, Biodistribution, and Dosimetry of Encapsulated Radio-Scandium in a Dendrimer for Radio-nano-pharmaceutical Application.

This study aimed to investigate the synthesis, characterization, and biodistribution of scandium nanoparticles encapsulated within poly (amidoamine) (PAMAM) dendrimers, as well as to estimate the human absorbed dose. It also aimed to examine, in particular, the amine-terminated PAMAM dendrimers in generation 5. Irradiation of the compound in the nuclear reactor resulted in the formation of Sc-radioactive complex nanoparticles.

Dosimetry of Ytterbium-poly (amidoamine) Therapy for Humans' Organs.

Purpose: This investigation focuses on biodistribution of irradiated dendrimer encapsulated ytterbium-175 (Yb) and to estimate the absorbed dose from intravenous injection of PAMAM encapsulated Yb to human organs.

Methods: A dendrimer compound containing an average of 55 Yb ions per dendrimer was prepared and irradiated with neutrons for 2h at 3×10 n.cm-s- neutron flux.

Development of Dendrimer Encapsulated Radio-Ytterbium and Biodistributionin Tumor Bearing Mice.

The aim of this study is preparation of dendrimer encapsulated ytterbium-175 radio-nanoparticles and investigation of the compound chemical characteristic before and after the neutron irradiation and also study the in vivo biodistribution for targeted radiopharmaceutical dose delivery to solid tumors. For preparation of dendrimer-metal nanocomposite, a dendrimer compound containing an average of 55 Yb ions per dendrimer was prepared. The synthesized encapsulated ytterbium irradiated by neutron for 2 h at 3×10 n.