Precision nutrition-based strategy for management of human diseases and healthy aging: current progress and challenges forward.

Currently, the treatment of various human ailments is based on different therapeutic approaches including traditional and modern medicine systems. Precision nutrition has come into existence as an emerging approach considering the diverse aspects such as age, sex, genetic and epigenetic makeup, apart from the pathophysiological conditions. The continuously and gradually evolving disciplines of genomics about nutrition have elucidated the importance of genetic variations, epigenetic information, and expression of myriads of genes in disease progression apart from the involvement in modulating therapeutic responses.

Development of Drug-Loaded PCL@MOF Film Enclosed in a Photo Polymeric Container for Sustained Release.

The programmed fabrication of oral dosage forms is associated with several challenges such as controlled loading and disintegration. To optimize the drug payload, excipient breakdown, and site-specific sustained release of hydrophobic drug (sulfamethoxazole, SM), we propose the development of acrylate polymer tablets enclosed with drug-loaded polycaprolactone (PCL) films. The active pharmaceutical ingredient (API) is physisorbed into the porous iron (Fe)-based metal-organic framework (MOF) and later converted to tangible PCL films, which, upon folding, are incorporated into the acrylate polymer matrices (P1/P2/P3).

Synergistic impact of and sp. ISTPL4 on the mitigation of arsenic stress in rice.

Arsenic (As) is a highly toxic metal that interferes with plant growth and disrupts various biochemical and molecular processes in plants. In this study, the harmful effects of As on rice were mitigated using combined inoculation of a root endophyte and an actinobacterium sp. ISTPL4.

Green Synthesis of Highly Fluorescent NCQDs: A Comprehensive Study on Synthesis, Characterization, Photophysical Properties, pH Sensing, Heavy Metal Detection, and Solvatochromic Behavior through Hydrothermal Method.

Solvatochromic studies in conjunction with NCQDs and analysis of material at different pH levels provide valuable insights about the process of metal ion sensing. Metal ion sensing holds significant importance in various fields like environment monitoring, biomedical diagnostics and various industrial purpose. The detection of metal ions by mixing the nitrogen-doped quantum dots (NCQDs) in the solvent at different pH levels for the analysis of the photoluminescence spectra is the unique property to achieve selective metal ion detection.

A concise review on waste biomass valorization through thermochemical conversion.

Due to an increase in industrialization and urbanization, massive amounts of solid waste biomass are speedily accumulating in our environment, which poses several adverse effects on habitat and human health thus becoming a matter of discussion in the environmental community. With reference to the circular economy, continuous efforts have been put forward for setting up an organised management approach in combination with an efficient treatment technique for increasing the profitable utilization of solid waste. This review aims to provide a systematic discussion on the recent thermochemical technologies employed for converting waste biomass generated from different sources into valuable products like biochar, bio-oil, heat, energy and syngas.

A review on metal/metal oxide nanoparticles in food processing and packaging.

Consuming hygienic and secure food has become challenging for everyone. The preservation of excess food without negatively affecting its nutritional values, shelf life, freshness, or effectiveness would undoubtedly strengthen the food industry. Nanotechnology is a new and intriguing technology that is currently being implemented in the food industry.

Fungal-Bacterial Combinations in Plant Health under Stress: Physiological and Biochemical Characteristics of the Filamentous Fungus and the Actinobacterium sp. ISTPL4 under In Vitro Arsenic Stress.

Fungal-bacterial combinations have a significant role in increasing and improving plant health under various stress conditions. Metabolites secreted by fungi and bacteria play an important role in this process. Our study emphasizes the significance of secondary metabolites secreted by the fungus alone and by an actinobacterium sp.

Nanomaterial-Coated Carbon-Fiber-Based Multicontact Array Sensors for In Vitro Monitoring of Serotonin Levels.

In this study, we demonstrated the fabrication of multicontact hierarchical probes for the in vitro detection of serotonin levels. The basic three-dimensional (3D) bendable prototypes with 3 (C1), 6 (C2), or 9 (C3) contact surfaces were printed from polymeric resin via the digital light processing (DLP) technique. We chose ultrasonicated carbon fiber strands to transform these designs into multicontact carbon fiber electrodes (MCCFEs).

A concise review on wastewater treatment through microbial fuel cell: sustainable and holistic approach.

Research for alternative sources for producing renewable energy is rising exponentially, and consequently, microbial fuel cells (MFCs) can be seen as a promising approach for sustainable energy production and wastewater purification. In recent years, MFC is widely utilized for wastewater treatment in which the removal efficiency of heavy metal ranges from 75-95%. They are considered as green and sustainable technology that contributes to environmental safety by reducing the demand for fossil fuels, diminishes carbon emissions, and reverses the trend of global warming.

Evolution of Transdermal Drug Delivery Devices and Novel Microneedle Technologies: A Historical Perspective and Review.

The history of transdermal drug delivery is as old as humankind. Transdermal drug delivery has undergone three generations of development; the third generation has involved the use of medical devices and instruments. This review provides a historical perspective on the primary approaches employed in the three generations of transdermal drug delivery.

Interaction studies of and sp. ISTPL4 and their synergistic role in growth promotion in rice.

Rapid urbanization and globalization demand increasing agricultural productivity. Soil nutrient supply capacity is continuously decreasing due to soil erosion, degradation, salt deposition, undesired element, metal deposition, water scarcity, and an uneven nutrient delivery system. Rice cultivation requires a large amount of water which is becoming detrimental due to these activities.

Exploring the intersection of Aspergillus fumigatus biofilms, infections, immune response and antifungal resistance.

Aspergillus fumigatus is an opportunistic pathogen that primarily affects the lungs and frequently elicits an allergic immune response in human hosts via inhalation of its airborne asexual spores (conidia). In immunocompromised individuals, the conidia of this fungus can germinate in the lung and result in severe systemic infections characterised by widespread tissue and organ damage. Conversely, in healthy hosts, the innate immune system is instrumental in eliminating the conidia and preventing disease progression.

Probe sonication-assisted rapid synthesis of highly fluorescent sulfur quantum dots.

A new type of heavy-metal free single-element nanomaterial, called sulfur quantum dots (SQDs), has gained significant attention due to its advantages over traditional semiconductor QDs for several biomedical and optoelectronic applications. A straightforward and rapid synthesis approach for preparing highly fluorescent SQDs is needed to utilize this nanomaterial for technological applications. Until now, only a few synthesis approaches have been reported; however, these approaches are associated with long reaction times and low quantum yields (QY).

Bacterial Pigments and Their Multifaceted Roles in Contemporary Biotechnology and Pharmacological Applications.

Synthetic dyes and colourants have been the mainstay of the pigment industry for decades. Researchers are eager to find a more environment friendly and non-toxic substitute because these synthetic dyes have a negative impact on the environment and people's health. Microbial pigments might be an alternative to synthetic pigments.

Etiology of cervicitis: Are there new agents in play?

Background: Considering the changing causative and resistance pattern of agents implicated in sexually transmitted infections (STIs), etiological diagnosis is imperative, especially in countries practicing syndromic management. This study was designed to identify etiological agents associated with cervicitis and to analyze their association with clinical and behavioral profile.

Materials And Methods: Female STI clinic attendees presenting with cervico-vaginal discharge were examined for the presence of cervicitis.

Revisiting the role of cyanobacteria-derived metabolites as antimicrobial agent: A 21st century perspective.

Cyanobacterial species are ancient photodiazotrophs prevalent in freshwater bodies and a natural reservoir of many metabolites (low to high molecular weight) such as non-ribosomal peptides, polyketides, ribosomal peptides, alkaloids, cyanotoxins, and isoprenoids with a well-established bioactivity potential. These metabolites enable cyanobacterial survival in extreme environments such as high salinity, heavy metals, cold, UV-B, etc. Recently, these metabolites are gaining the attention of researchers across the globe because of their tremendous applications as antimicrobial agents.

Biochar-based fertilizers and their applications in plant growth promotion and protection.

Soil is an integral part of the ecosystem because it serves as a habitat for various microorganisms and lays the foundation for supporting plant growth and development. Therefore, factors such as increased anthropogenic activities hand by hand with other natural processes that harm the ecosystem may eventually lead to a decline in soil quality and fertility, hindering the growth of plants and soil microbial communities. Given the current global scenario of increasing human intervention, it is essential to find effective measures and reliable technologies to restore soil quality.

Novel photonic methods for diagnosis of SARS-CoV-2 infection.

The COVID-19 pandemic that began in March 2020 continues in many countries. The ongoing pandemic makes early diagnosis a crucial part of efforts to prevent the spread of SARS-CoV-2 infections. As such, the development of a rapid, reliable, and low-cost technique with increased sensitivity for detection of SARS-CoV-2 is an important priority of the scientific community.

An Integrative Approach to Study Bacterial Enzymatic Degradation of Toxic Dyes.

Synthetic dyes pose a large threat to the environment and consequently to human health. Various dyes are used in textile, cosmetics, and pharmaceutical industries, and are released into the environment without any treatment, thus adversely affecting both the environment and neighboring human populations. Several existing physical and chemical methods for dye degradation are effective but have many drawbacks.

Cold plasma technology: advanced and sustainable approach for wastewater treatment.

Cold plasma has been a potent energy-efficient and eco-friendly advanced oxidation technology which has gained attention in recent decades as a non-thermal approach in diverse forms of applications. This review highlights a comprehensive account of the implementation of this technology in the field of wastewater treatment to resolve certain issues regarding the degradation of numerous aqueous pollutants and water-borne pathogenic microorganisms including viruses up to a significant level. The paper addresses plasma chemistry sources and mechanisms on wastewater treatment and impact on various physical, chemical, and biological characteristics of treated water.

Facets of rhizospheric microflora in biocontrol of phytopathogen Macrophomina phaseolina in oil crop soybean.

The use of microbial bioinoculants for managing plant diseases and promoting plant growth is an effective alternative approach to integrated farming. One of the devastating phytopathogens is Macrophomina phaseolina (Tassi) Goid. It is an omnipresent fungus infecting more than 500 plant species.

Novel sulphur-oxidizing bacteria consummate sulphur deficiency in oil seed crop.

Plants absorb sulphate, the oxidized form of elemental sulphur (S°), from soil. Sulphur-oxidizing bacteria play a key role in transformation of sulphur in soil. Oil seed crops require high amount of sulphur and it plays an important role in the formation of proteins, vitamins and enzymes.

Extremophile - An Adaptive Strategy for Extreme Conditions and Applications.

The concurrence of microorganisms in niches that are hostile like extremes of temperature, pH, salt concentration and high pressure depends upon novel molecular mechanisms to enhance the stability of their proteins, nucleic acids, lipids and cell membranes. The structural, physiological and genomic features of extremophiles that make them capable of withstanding extremely selective environmental conditions are particularly fascinating. Highly stable enzymes exhibiting several industrial and biotechnological properties are being isolated and purified from these extremophiles.

Production, purification and applications of raw starch degrading and calcium-independent α-amylase from soil rich in extremophile.

Calcium independent, raw starch hydrolyzing, acidic α-amylase (66 kDa) was synthesized by Bacillus subtilis S113 that is an aerobic, rod-shaped and Gram +ve bacteria. Purification of the enzyme was performed by HiTrap Capto Q (Ion-exchange chromatography; 19.28 fold; 22.