Publications by authors named "Navarro G"

High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

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  • GPR88 is an orphan G protein-coupled receptor primarily found in the striatum, and its function is not well understood despite changes in its expression seen in Parkinson's disease models.
  • GPR88 was found to interact with the kappa-opioid receptor (KOR), and this interaction inhibits KOR-mediated signaling, as evidenced by experiments showing that GPR88 can modulate effects of KOR agonists in both cultured cells and primary striatal neurons.
  • The GPR88-KOR complexes were more common in specific neurons related to dopamine pathways, suggesting that understanding their relationship could have implications for conditions like neuropathic pain, Parkinson's disease, and neuropsychiatric disorders.
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  • - Calcium ion (Ca) homeostasis is essential for proper neuron function, and this study investigated how the CB receptor (CBR) interacts with the ATR receptor to regulate cytoplasmic Ca levels in CNS neurons.
  • - A specific type of interaction called AT-CB receptor heteromers (ATCBHets) was identified using bioluminescence resonance energy transfer (BRET) in lab cells and in the context of Parkinson's disease (PD).
  • - The study found that activation of ATR reduces Ca levels in the presence of cannabinoids, and in a rat model of PD, lower levels of ATCBHets were linked to lesioned neurons, suggesting that cannabinoids might help mitigate calcium imbalance related to levodopa-induced
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A search for the exclusive hadronic decays W^{±}→π^{±}γ, W^{±}→K^{±}γ, and W^{±}→ρ^{±}γ is performed using up to 140  fb^{-1} of proton-proton collisions recorded with the ATLAS detector at a center-of-mass energy of sqrt[s]=13  TeV. If observed, these rare processes would provide a unique test bench for the quantum chromodynamics factorization formalism used to calculate cross sections at colliders. Additionally, at future colliders, these decays could offer a new way to measure the W boson mass through fully reconstructed decay products.

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  • - The ATLAS experiment at the LHC conducted a search for long-lived particles (LLPs) using a large dataset (140 fb^{-1}) from proton-proton collisions at 13 TeV, focusing on LLPs with masses from 5 to 55 GeV that decay within the inner detector.
  • - The study considered scenarios where LLPs are produced from exotic Higgs boson decays and models involving axionlike particles (ALPs).
  • - No significant findings above expected background levels were detected, leading to the establishment of upper limits on various production rates involving the Higgs boson and the top quark related to LLPs and ALPs.
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Microphytobenthos (MPB) contributes significantly to estuarine primary production, so that quantifying its biomass is crucial for assessing their ecosystem functioning. Conventional sampling methods are labour-intensive, logistically challenging, and cannot provide a comprehensive spatial distribution map of MPB biomass. Satellite imagery has offered a feasible alternative for mapping large areas at various temporal and spatial resolutions.

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  • The study investigates the associated production of Higgs and W bosons, focusing on how the relative signs of the Higgs couplings to W and Z bosons impact the process.
  • Two specific searches were conducted using large amounts of collision data from the LHC to analyze different coupling scenarios: one for opposite-sign couplings and another for same-sign (standard model-like) couplings.
  • The results significantly exclude the opposite-sign coupling hypothesis and set a strict upper limit on the production rate of this process compared to standard model predictions.
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  • The International Space Station's current food supply method won't work for deep space missions, necessitating alternative food sources.
  • This study investigates using the bacterium Cupriavidus necator to convert urea and volatile fatty acids (VFAs) into single-cell protein.
  • Results showed higher protein content in biomass when using lower dilution rates, increasing protein levels while decreasing undesirable components like nucleic acids and polyhydroxyalkanoates.
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This Letter presents results from a combination of searches for Higgs boson pair production using 126-140  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV recorded with the ATLAS detector. At 95% confidence level (CL), the upper limit on the production rate is 2.9 times the standard model (SM) prediction, with an expected limit of 2.

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This Letter presents the first study of the energy dependence of diboson polarization fractions in WZ→ℓνℓ^{'}ℓ^{'}(ℓ,ℓ^{'}=e,μ) production. The dataset used corresponds to an integrated luminosity of 140  fb^{-1} of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the ATLAS detector. Two fiducial regions with an enhanced presence of events featuring two longitudinally polarized bosons are defined.

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  • Class A G protein-coupled receptors (GPCRs) are important for cell signaling and are major drug targets, yet over 60% of them remain untapped for therapeutic use.
  • Traditional GPCR drugs often have adverse effects, but biased signaling offers a new approach for discovering safer therapeutics by targeting specific receptor conformations.
  • The review outlines the landscape of GPCR-biased modulators, highlighting recent advancements, therapeutic relevance, and the variations in understanding their biological effects across different GPCR families.
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  • G protein-coupled receptors (GPCRs) are dynamic structures that can exist in different forms and are influenced by ligand binding, balancing between monomers and oligomers.
  • A new bivalent ligand, which contains two linked pharmacophore units, can affect the behavior of the cannabinoid CB receptor (CBR) by binding to both parts of its dimer form.
  • This binding leads to increased signaling potency and better recruitment of β-arrestin, suggesting that manipulating receptor dimerization could enhance therapeutic effects for treatments involving cannabinoid receptors.
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MONI (Rossi et al., 2022) is a BWT-based compressed index for computing the matching statistics and maximal exact matches (MEMs) of a pattern (usually a DNA read) with respect to a highly repetitive text (usually a database of genomes) using two operations: LF-steps and longest common extension (LCE) queries on a grammar-compressed representation of the text. In practice, most of the operations are constant-time LF-steps but most of the time is spent evaluating LCE queries.

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  • A study was conducted to create a risk score to predict loss to follow-up (LTFU) in patients living with HIV (PLWH) in Catalonia and the Balearic Islands.
  • The study analyzed 6,661 PLWH and identified key factors contributing to LTFU, including age, nationality, drug use, viral load, and time since diagnosis.
  • The results indicated that a significant portion of PLWH (28.8%) was at medium risk and 3.4% at high risk for LTFU, highlighting the need for targeted interventions to retain patients in HIV care.
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For taxonomic classification, we are asked to index the genomes in a phylogenetic tree such that later, given a DNA read, we can quickly choose a small subtree likely to contain the genome from which that read was drawn. Although popular classifiers such as Kraken use -mers, recent research indicates that using maximal exact matches (MEMs) can lead to better classifications. For example, we can ■ build an augmented FM-index over the the genomes in the tree concatenated in left-to-right order; ■ for each MEM in a read, find the interval in the suffix array containing the starting positions of that MEM's occurrences in those genomes; ■ find the minimum and maximum values stored in that interval; ■ take the lowest common ancestor (LCA) of the genomes containing the characters at those positions.

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Statistical combinations of searches for charginos and neutralinos using various decay channels are performed using 139  fb^{-1} of pp collision data at sqrt[s]=13  TeV with the ATLAS detector at the Large Hadron Collider. Searches targeting pure-wino chargino pair production, pure-wino chargino-neutralino production, or Higgsino production decaying via standard model W, Z, or h bosons are combined to extend the mass reach to the produced supersymmetric particles by 30-100 GeV. The depth of the sensitivity of the original searches is also improved by the combinations, lowering the 95% C.

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  • Allosterism is a regulatory mechanism for G protein-coupled receptors (GPCRs) that can be affected by ligand binding or interactions between different GPCRs; the study focuses on the allosteric properties of A receptor and CB receptor when they form a heteromer.
  • Experimental techniques used include measuring cAMP levels, analyzing phosphorylation of kinases, and using dynamic mass redistribution methods, showing how disrupting the heteromer affects receptor activation.
  • Key findings reveal that the A receptor can inhibit signaling in the CB receptor by blocking essential structural components, and that certain antagonists can change the interaction dynamics to allow for receptor activation, highlighting a unique allosteric mechanism in GPCR signaling.
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BiTe is a well-known thermoelectric material that was first investigated in the 1960s, optimized over decades, and is now one of the highest performing room-temperature thermoelectric materials to-date. Herein, we report on the colloidal synthesis, growth mechanism, and thermoelectric properties of BiTe nanoplates with a single nanopore in the center. Analysis of the reaction products during the colloidal synthesis reveals that the reaction progresses via a two-step nucleation and epitaxial growth: first of elemental Te nanorods and then the binary BiTe nanoplate growth.

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  • * The measurements utilized both semileptonic and hadronic decays of top quarks, along with events focused on single top quark production in the electroweak t channel.
  • * The combined result for the top quark mass is 172.52 GeV, with a reduced total uncertainty of 0.33 GeV, showcasing an improvement of 31% over previous measurements.
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  • Neuroinflammatory disorders are linked to mitochondrial dysfunction and transcriptional changes, particularly in activated microglia, which shows altered biogenesis and redox status.
  • This study utilized RNA sequencing to examine gene expression in microglia treated with adenosine A receptor modulators, revealing significant upregulation (over 40% of mitochondrial genes expressed differently) in response to treatment, highlighting their role in inflammation and oxidative stress.
  • The research also indicated improved mitochondrial function when using the adenosine A receptor antagonist in pro-inflammatory conditions, supporting the potential of targeting the adenosinergic system for therapeutic interventions in neuroinflammation.
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Background: Aseptic loosening (AL) is a frequent complication after rotating hinge knee (RHK) prosthesis. Citak's ratio has recently been developed to describe and classify distal femoral morphology into 3 groups (A, B, C). It consists in a ratio between the diameters of the femoral canal at 20 cm from the knee joint line and at 2 cm from the adductor tubercle.

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  • Stroke is a major global health issue, affecting 15 million people annually and leaving millions dead or disabled, highlighting the need for new treatments to prevent cognitive decline and neuronal death.
  • Phytocannabinoids are traditional compounds known for their neuroprotective benefits, but their psychoactive effects have limited their use in medicine, prompting research for non-psychoactive alternatives.
  • Advances in cannabinoid receptor research, including the development of heteromers and the approval of certain CBD and Δ-THC combinations for specific conditions, represent promising new therapeutic avenues for neurodegenerative diseases and other disorders.
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A combination of searches for a new resonance decaying into a Higgs boson pair is presented, using up to 139  fb^{-1} of pp collision data at sqrt[s]=13  TeV recorded with the ATLAS detector at the LHC. The combination includes searches performed in three decay channels: bb[over ¯]bb[over ¯], bb[over ¯]τ^{+}τ^{-}, and bb[over ¯]γγ. No excess above the expected Standard Model background is observed and upper limits are set at the 95% confidence level on the production cross section of Higgs boson pairs originating from the decay of a narrow scalar resonance with mass in the range 251 GeV-5 TeV.

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In this study, a critical review was carried out using the Web of Science Core Collection database to analyse the scientific literature published to date to identify lines of research and future perspectives on the presence of chemical pollutants in beer brewing. Beer is one of the world's most popular drinks and the most consumed alcoholic beverage. However, a widespread challenge with potential implications for human and animal health is the presence of physical, chemical, and/or microbiological contaminants in beer.

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Higgsinos with masses near the electroweak scale can solve the hierarchy problem and provide a dark matter candidate, while detecting them at the LHC remains challenging if their mass splitting is O(1  GeV). This Letter presents a novel search for nearly mass-degenerate Higgsinos in events with an energetic jet, missing transverse momentum, and a low-momentum track with a significant transverse impact parameter using 140  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV collected by the ATLAS experiment. For the first time since LEP, a range of mass splittings between the lightest charged and neutral Higgsinos from 0.

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