Publications by authors named "Navapan Issariyakulkarn"

Introduction: Association of Southeast Asian Nations (ASEAN) countries have high infections, and gastric cancer (GC) is a leading fatal cancer in this region, especially in female patients. This study aimed to compare clinical manifestations, histopathological subtypes, and prognostic factors associated with the overall survival rate of female GC patients in this important region.

Methods: This retrospective cohort study was conducted between 2007 and 2022 at a tertiary care center in Thailand.

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Background: Helicobacter pylori treatment failure remains a challenging problem. This study aimed to identify predictive factors for successful eradication in patients following treatment failures.

Methods: This was a retrospective cohort study.

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Background: Physical frailty is related with morbidity and mortality in patients with cirrhosis. Currently, there is no approved treatment of frailty in these patients. Here, we evaluated the efficacy of 16 weeks branched-chain amino acids (BCAA) supplementation on frailty in frail compensated cirrhotic patients.

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Article Synopsis
  • The study investigates the factors that can predict whether gastric intestinal metaplasia (IM) - a condition that can lead to gastric cancer - will improve or worsen, focusing on patients at Thammasat University Hospital in Thailand.
  • The researchers analyzed data from 2,025 patients, finding that factors like age over 65, ongoing H. pylori infection, and diabetes are linked to a higher risk of IM persistence or progression.
  • Results indicated that patients without H. pylori had better chances of regression of IM, while those with the infection were more likely to progress to dysplasia, and a small percentage were later diagnosed with gastric cancer during follow-up.
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Background And Aims: Frailty is associated with morbidity and mortality in advanced cirrhosis. However, the information on the association between frailty and outcome in compensated cirrhosis is scarce. We aimed to explore the prognostic impact of frailty in compensated cirrhosis.

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This work summarizes new and emerging metrics and tools in esophageal function testing and their potential clinical impact. Because the diagnostic sensitivity and reliability of conventional impedance-pH variables are suboptimal, several novel impedance parameters, such as the postreflux swallow-induced peristaltic wave index and the mean nocturnal baseline impedance, as well as mucosal impedance, are entering a validation stage prior to general clinical use. The accurate diagnosis of behavioral disorders in patients with rumination syndrome and supragastric belching using ambulatory multiple intraluminal impedance-pH can lead directly to behavioral interventions in patients with refractory gastroesophageal reflux disease (GERD).

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