Cochrane Database Syst Rev
February 2010
Background: Gastro-oesophageal reflux disease (GORD) - reflux of stomach contents +/- bile into the oesophagus causing symptoms such as heartburn and acid reflux - is a common relapsing and remitting disease which often requires long-term maintenance therapy. Patients with GORD may have oesophagitis (inflammation of the oesophagus) or a normal endoscopy (endoscopy negative reflux disease or ENRD).
Objectives: To assess the effects of continuous maintenance therapy in adults with GORD (both ENRD and healed oesophagitis).