The Investigating Image Registration Accuracy and Contour Propagation for Adaptive Radiotherapy Purposes in Line with the Task Group No. 132 Recommendation.

Purpose: Image registration is a crucial component of the adaptive radiotherapy workflow. This study investigates the accuracy of the deformable image registration (DIR) and contour propagation features of SmartAdapt, an application in the Eclipse treatment planning system (TPS) version 16.1.

A DNA repair player, ring finger protein 43, relieves etoposide-induced topoisomerase II poisoning.

Ring finger protein 43 (RNF43) is an E3 ubiquitin ligase which is well-known for its role in negative regulation of the Wnt-signaling pathway. However, the function in DNA double-strand break repairs has not been investigated. In this study, we used a lymphoblast cell line, DT40, and mouse embryonic fibroblast as cellular models to study DNA double-strand break (DSB) repairs.

Two-dimensional solid-state array detectors: A technique for in vivo dose verification in a variable effective area.

Purpose: We introduce a technique that employs a 2D detector in transmission mode (TM) to verify dose maps at a depth of d in Solid Water. TM measurements, when taken at a different surface-to-detector distance (SDD), allow for the area at d (in which the dose map is calculated) to be adjusted.

Methods: We considered the detector prototype "MP512" (an array of 512 diode-sensitive volumes, 2 mm spatial resolution).

Technical Note: Angular dependence of a 2D monolithic silicon diode array for small field dosimetry.

Purpose: This study aims to investigate the 2D monolithic silicon diode array size of 52 × 52 mm (MP512) angular response. An angular correction method has been developed that improves the accuracy of dose measurement in a small field.

Methods: The MP512 was placed at the center of a cylindrical phantom, irradiated using 6 MV and 10 MV photons and incrementing the incidence of the beam angle in 15° steps from 0° to 180°, and then in 1° steps between 85° and 95°.