Corrective wedge ostectomy for an atypical femoral procurvatum deformity stabilised with a supracondylar bone plate.

Physeal fractures of the distal femur are among the most commonly encountered fractures in skeletally immature dogs. These fractures respond poorly to conservative management and thus early surgical reduction and stabilisation are recommended. A 7-month-old intact male Border collie presented with a history of chronic lameness.

Accuracy of Diffusion-weighted Magnetic Resonance Colonography in Assessing Mucosal Healing and the Treatment Response in Patients with Ulcerative Colitis.

Background And Aims: Using sigmoidoscopy as the gold standard, we assessed the accuracy, and the responsiveness to change, of diffusion-weighted magnetic resonance colonography in ulcerative colitis, using the Nancy score.

Methods: A total of 29 ulcerative colitis patients, having undergone at least two diffusion-weighted magnetic resonance colonographies, were included. Disease activity was evaluated using the Mayo endoscopic subscore and the Nancy score.

Retreatment with TACE: the ABCR SCORE, an aid to the decision-making process.

Background & Aims: Transarterial chemoembolization (TACE) is the standard of care for intermediate stage hepatocellular carcinoma (HCC) and it is the most commonly used treatment for HCC worldwide. However, no prognostic indices, designed to select appropriate candidates for repeat conventional TACE, have been incorporated in the guidelines.

Methods: From January 2007 to April 2012, 139 consecutive HCC patients, mainly with an alcohol- or viral-induced disease, were treated with TACE.

Association of preoperative magnetic resonance imaging findings with surgical features in Dachshunds with thoracolumbar intervertebral disk extrusion.

Objective: To evaluate the accuracy of specific magnetic resonance imaging (MRI) sequences in determining the site, lateralization, and extent of extruded intervertebral disk material (EIDM), compared with surgical findings, in Dachshunds with thoracolumbar intervertebral disk extrusion (TLIDE).

Design: Prospective clinical study.

Sample Population: 16 Dachshunds with clinical signs of intervertebral disk disease.

Magnetic resonance imaging findings of a metastatic chemodectoma in a dog.

A 6-year-old, male, Collie-cross was presented with a non-weight bearing right thoracic limb lameness, right m. deltoideus, m. infraspinatus and m.

Development of a novel self-medicating applicator for control of internal and external parasites of wild and domestic animals.

Four trials, three in the United States and one in South Africa, were conducted to evaluate the potential value of a novel self-medicating applicator in the passive control of gastrointestinal nematodes in cattle and deer, and of files and ticks on cattle using oil-based treatments. The results of the trials demonstrated that this applicator is an effective and practical device for the passive treatment of both deer and cattle for trichostrongyle infections using the endectocide, moxidectin (Cydectin. Fort Dodge Animal Health, USA), of cattle for hom fly (Haemotobia irritans) infestations using the insecticide, cyfluthrin (CyLence, Bayer AG, Germany) and of cattle for tick infestations (in particular Amblyomma hebraeum and Rhipicephalus appendiculatus) using the acaricides deltamethrin and amitraz (Delete All, Intervet, South Africa).

Galectin-3 expression in normal, hyperplastic, and neoplastic endometrial tissues.

This study evaluated the expression of galectin-3 in 101 curettage specimens from normal, hyperplastic, and neoplastic endometrial tissues using immunohistochemistry. The histologic diagnoses were as follows: normal proliferative (n = 8) and secretory (n = 4) phase, simple hyperplasia (SH, n = 16), complex hyperplasia without atypia (CH, n = 11), atypical hyperplasia (AH, n = 13), endometrioid adenocarcinoma (EC, n = 35), serous papillary carcinoma (SPC, n = 10), and clear cell carcinoma (CC, n = 4). Immunostaining was scored with regard to the approximate percentage of positive tumor cells and relative staining intensity.

The flow-pressure plot: a new look on the patient-ventilator interaction in neonatal care.

Most modern neonatal ventilators have now a built-in flow sensor and, as a spin-off of their mechanical action, provide some information about lung function characteristics as compliance and resistance after computation of the flow and pressure signals. Additionally, respiratory graphics as volume-pressure and flow-volume plots can be displayed. In clinical practice, however, they are rarely used to refine the ventilator setting.

Expression of topoisomerase IIalpha, Ki-67, proliferating cell nuclear antigen, p53, and argyrophilic nucleolar organizer regions in vulvar squamous lesions.

Objective: It was the aim of this study to investigate the expression of topoisomerase IIalpha (topo IIalpha), Ki-67, proliferating cell nuclear antigen (PCNA), p53, and argyrophilic nucleolar organizer region (AgNOR) staining in normal vulvar epithelia (NE, N = 10), vulvar condylomas (VC, N = 24), vulvar intraepithelial neoplasia (VIN, N = 26), as well as squamous cell carcinomas (SCC, N = 22) of the vulva.

Methods: Formalin-fixed, paraffin-embedded archival tissue sections were immunostained with monoclonal antibodies against topo IIalpha, p53, and PCNA, as well as an affinity-isolated prediluted ready-to-use Ki-67 antibody using a standard immunohistochemical method, and stained with a colloid silver solution for AgNORs. Immunostaining was quantitated by determining the percentage of positively staining nuclei in each sample to express the labeling indices (LIs) by counting the immunoreactive nuclei in 1000 epithelial cells per case for each antibody.

Legislative issues impacting on the practice of the South African nurse practitioner.

Purpose: To present an overview of the impact of the nurse practitioner (NP) on the South African health care arena and describe the legislative framework for NP practice.

Data Sources: Statutes and laws of the government of South Africa; published professional guidelines; authors' experiences.

Conclusions: The key challenges for NPs in South Africa lie in lobbying for enabling legislation, obtaining access to education and training opportunities, and managing risks within the rapidly changing environment.

Vascular endothelial growth factor expression in serous ovarian carcinoma: relationship with high mitotic activity and high FIGO stage.

Objective: The aim of this study was to investigate the expression of vascular endothelial growth factor (VEGF) by neoplastic cells in serous ovarian cystadenocarcinoma in relation to proliferation as determined by mitotic activity and to FIGO stage.

Materials And Methods: Formalin-fixed, paraffin-embedded archival tissue from 10 benign serous cystadenomas and 45 serous carcinomas was immunostained with a polyclonal antibody to VEGF (Biogenex) utilizing the LSAB kit, alkaline phosphatase (Dako). Positivity was scored as (0) for no, (+) for weak, and (++) for strong staining.

Iron supplementation in preterm infants: a study comparing the effect and tolerance of a Fe2+ and a nonionic FeIII compound.

The more widely used divalent forms of iron (Fe2+) supplementation often lead to gastrointestinal symptoms in preterm infants although little is known about the use of nonionic trivalent iron preparations (FeIII) in these patients. It is especially under this nonionic form that dietary iron is available. For this reason, a randomized controlled study was undertaken to compare the efficacy and the extent of possible side effects in two groups of preterm infants.

Expression of nm23 in normal, hyperplastic and neoplastic endometrial tissues.

This study evaluated the expression of nm23 in curettage specimens from 63 cases of normal, hyperplastic and neoplastic endometrial tissues by immunohistochemistry. The histological diagnoses were as follows: normal proliferative (N = 5) or secretory (N = 5), simple hyperplasia (N = 11), complex hyperplasia (N = 9), atypical hyperplasia (N = 8) and adenocarcinoma (N = 25), consisting of endometrioid adenocarcinoma (N = 15), clear cell (N = 7) and serous papillary adenocarcinoma (N = 3). There was no immunostaining for nm23 protein in the 10 cases of normal endometria and in the 28 cases of endometrial hyperplasia.

The relevance of angiogenesis in benign and malignant epithelial tumors of the ovary: a quantitative histologic study.

The ability of a tumor to grow and eventually to infiltrate adjacent tissues requires a sufficient blood supply. Many malignant neoplasms have been shown to induce neovascularization. We asked whether it is possible to characterize ovarian epithelial tumors on the basis of vascularization and whether vascularization can be used to differentiate between benign and malignant neoplasms.

Nucleolar organizer regions as markers of endometrial proliferation: a study of normal, hyperplastic, and neoplastic tissue.

Nucleolar organizer regions (NORs) are loops of DNA that transcribe to ribosomal RNA. They can be visualized as intranuclear black dots by histochemical staining with a colloid silver solution. We applied this method to 78 sections of endometrial tissue obtained either from curettage or from hysterectomy specimens.

[Histochemical characterization of endometrial proliferation using AgNOR (nucleolus organizer region)].

Nucleolar organizer regions (NORs) are loops of DNA that transcribe to ribosomal RNA. We used histochemical staining of NORs for 78 sections of endometrial tissue, obtained either from curettage or from hysterectomy specimens (normal endometrium 14, simple hyperplasia 10, complex hyperplasia 18, atypical hyperplasia 8 and adenocarcinoma 28). There was a significant positive correlation between mean AgNOR counts and the degree of hyperplasia.

Accidental poisoning in childhood.

A study to determine the circumstances under which children ingested potentially noxious substances and also to ascertain the pharmacological nature and physical appearance of the substances was undertaken. The results suggest that depending on the watchfulness of adults alone is inadequate to prevent accidental poisoning. Measures to reduce the incidence, morbidity and mortality of childhood poisoning are discussed.

Benoxaprofen: a pro-oxidant anti-inflammatory drug?

Benoxaprofen inhibited the random motility and migration to the leucoattractants endotoxin-activated serum (EAS) and f-met-leu-phe of human polymorphonuclear leucocytes (PMNL) in vitro. Inhibition of random and leucoattractant-induced migration was observed at drug concentrations of greater than 1 X 10(-6) M and 1 X 10(-5) M respectively. Benoxaprofen per se was not leucotactic but was pro-oxidative in that it stimulated PMNL hexose-monophosphate shunt activity, chemiluminescence, myeloperoxidase-mediated iodination reactions and degranulation.

The antirheumatic effect of benoxaprofen.

This study was undertaken to investigate the antirheumatic activity of the non-steroidal anti-inflammatory drug benoxaprofen. Ten patients with definite or classic rheumatoid arthritis were assessed before beginning drug therapy, using standard clinical criteria and serological tests of disease activity. These tests were repeated monthly during treatment with benoxaprofen for a period of 6 months.

The effects of benoxaprofen on mononuclear and polymorphonuclear leucocyte motility. An in vitro and in vivo study.

Benoxaprofen at concentrations well within the normal therapeutic range was found to cause significant inhibition of both mononuclear leucocyte (MNL) and polymorphonuclear leucocyte (PMNL) motility in vitro. The ingestion of benoxaprofen 600 mg also resulted in a significant reduction of MNL migration, while co-incubation of control PMNLs with 25% heat-inactivated serum from healthy subjects resulted in a very significant inhibition of PMNL motility. Serum IgG levels also dropped significantly after benoxaprofen ingestion.