Mallotumides A-C: Potent Cytotoxic Cycloheptapeptides from the Roots of .

The structures of potent cytotoxic cycloheptapeptides, mallotumides A-C (-, respectively) isolated from the roots of Airy Shaw, were elucidated by extensive spectroscopic analysis. The absolute configuration of was determined by single-crystal X-ray crystallographic data. All three cycloheptapeptides exhibited potent cytotoxicity against various cancer cell lines with IC values ranging from 0.

Cascade Oxidative Trifluoromethylthiolation and Cyclization of 3-Alkyl-1-(2-(alkynyl)phenyl)indoles.

Persulfate-promoted radical cascade trifluoromethylthiolation and cyclization of 3-alkyl-1-(2-(alkynyl)phenyl)indoles with AgSCF were investigated. This protocol provides a novel route to CFS-substituted indolo[1,2-]quinoline-7-carbaldehydes and CFS-substituted indolo[1,2-]quinoline-7-methanone derivatives via the formation of the C-SCF bond and C-C bond and benzylic carbon oxidation in a single step. This reaction can accommodate a broad range of functional groups.