The expression of trefoil factor family member 2 in increased at an acidic pH.

Trefoil factor family member 2 () is significantly involved in intestinal tumor growth in mice, which can be used as a human colon cancer model. , which encodes TFF2 (spasmolytic protein 1) is highly expressed in human cancer tissues, including the pancreas, colon and bile ducts, as well as in normal gastric and duodenum tissues. By contrast, exhibits low expression levels in other normal tissues, including the small and large intestine.