Publications by authors named "Natsumi Sakai"
Effect of Benralizumab on Mucus Plugs in Severe Eosinophilic Asthma.
Int Arch Allergy Immunol
August 2023
Article Synopsis
- Mucus plugs are linked to airway obstruction in severe asthma, and the study investigates the impact of benralizumab, an anti-interleukin-5 receptor antibody, on these plugs using CT imaging.
- In a study involving 12 asthma patients, researchers found that the number of mucus plugs significantly decreased after 4 months of benralizumab treatment, correlating with improved asthma symptoms and lung function.
- The results indicate that benralizumab might enhance respiratory health and quality of life in severe eosinophilic asthma patients by effectively reducing mucus plugs and related eosinophil levels.
Article Synopsis
- Benralizumab is an antibody treatment for severe asthma that aims to improve symptoms and reduce flare-ups by targeting interleukin-5 receptors.
- A study on 11 patients revealed that those treated with benralizumab experienced significant improvements in asthma control, quality of life, and reduced exacerbations.
- CT imaging showed decreased airway wall thickness and increased total airway count, suggesting benralizumab effectively reduces airway obstruction and enhances lung ventilation.
Introduction: Psychological disorders, such as depression, are markedly prevalent in patients with airway diseases. In this study, we assessed the effect of treatment with dupilumab, an IL-4 receptor α chain antibody, on depressive symptoms in a cohort of patients with asthma with eosinophilic chronic rhinosinusitis (ECRS).
Methods: The study participants, diagnosed with asthma and ECRS, were assessed for symptoms and quality of life (QOL) scores for asthma and ECRS and medications.
Rab family small GTPases are master regulators of distinct steps of intracellular vesicle trafficking in eukaryotic cells. GDP-bound cytoplasmic forms of Rab proteins are prone to aggregation due to the exposure of hydrophobic groups but the machinery that determines the fate of Rab species in the cytosol has not been elucidated in detail. In this study, we find that BAG6 (BAT3/Scythe) predominantly recognizes a cryptic portion of GDP-associated Rab8a, while its major GTP-bound active form is not recognized.
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