Publications by authors named "Natsuko Hatsusaka"

Purpose: To evaluate changes in cataract and refractive surgery practice patterns among members of the Japanese Society of Cataract and Refractive Surgery (JSCRS) over the past 20 years.

Study Design: Questionnaire survey study.

Subjects And Methods: Clinical surveys were conducted annually between February and April from 2004 to 2023.

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  • * Participants were split into two groups: one for developing the prediction formula and another for validating its accuracy using advanced imaging techniques.
  • * The results showed a significant correlation between the predicted and actual measurements of anterior chamber depth, lens tilt, and decentration, indicating improved accuracy in predicting how well the intraocular lenses would adapt post-surgery.
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Epidemiological studies have reported that the frequency of nuclear cataracts (NUCs) is high among the elderly and in tropical countries. Ultraviolet (UV) irradiation and lens temperature are considered as key physical contributors, although their precise quantification is difficult. The aim of this study is to investigate the association of NUC prevalence with UV irradiation and heat load.

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Regulation of ion and water microcirculation within the lens is tightly controlled through aquaporin channels and connexin junctions. However, cataracts can occur when the lens becomes cloudy. Various factors can induce cataracts, including diabetes which is a well-known cause.

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Enhancement of density via human lens epithelium (HLE) cell proliferation is the underlying cause of nuclear cataracts. Moreover, our previous epidemiological study demonstrated that the risk of nuclear cataract development is significantly higher under elevated environmental temperatures compared with under lower temperatures. The present study investigated the relationship between temperature and cell proliferation in terms of mitochondrial function, which is a nuclear cataract‑inducing risk factor, using two different HLE cell lines, SRA01/04 and immortalized human lens epithelial cells NY2 (iHLEC‑NY2).

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  • This study examined how visual function declines in eyes with retrodots (a type of cataract) compared to transparent lenses.
  • It included 57 eyes with retrodots and analyzed aspects like visual acuity and optical characteristics using a classification system.
  • Results indicated that eyes with a higher opacity of retrodots (≥25%) experienced significant reductions in visual acuity, increased straylight, and greater myopia than those with lower opacity and control eyes.
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Purpose: To investigate the impact of the size and location of waterclefts (WC), which are one of several cataract subtypes, on visual function by optical simulation analysis.

Methods: An optical simulation software (CODE V) was used to develop a schematic eye model and several sizes of WC central and peripheral types that were located below the anterior and posterior subcapsules of the crystalline lens, and analyses of refraction, higher-order aberrations (HOA), and the modulation transfer function (MTF) were performed.

Results: An increase in the WC size increased the refraction and HOA and decreased the MTF.

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  • This study investigates the connection between pterygium, a growth on the eye surface caused by UV light, and different types of cataracts in individuals from areas with varying UV exposure.
  • It involved 1,547 participants from China and Taiwan, examining their UV exposure and grading pterygium and cataracts.
  • Results showed a 23.3% prevalence of pterygium, with four types of cataracts linked to its presence, suggesting that cumulative ocular UV exposure plays a significant role in the development of both pterygium and cataracts.
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Aim: To compare the preoperative biometric data and the refractive accuracy of cataract surgery among major surgical sites in a nationwide multicentre study.

Methods: We prospectively obtained the preoperative biometric data of 2143 eyes of 2143 consecutive patients undergoing standard cataract surgery at major 12 facilities and compared the preoperative biometry as well as the postoperative refractive accuracy among them.

Results: We found significant differences in most preoperative variables, such as axial length (one-way analysis of variance, p=0.

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Purpose: The ultraviolet index (UVI), available online, is an international linear scale of levels from 0 to 13+ that warns about the risk of sunburn; however, it does not address the risk to eyes. Our purpose was to develop a useful instrument to warn the public against ocular ultraviolet (OUV) exposure and to serve as a tool for researching UV-induced ocular diseases.

Methods: A rotating model head that included ultraviolet B (UVB) sensors documented UV irradiance at the crown and at the eyes spanning eight azimuths from sunrise to sunset under different climatic conditions in each season.

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  • Researchers developed induced pluripotent stem (iPS) cells from human iris cells to regenerate retinal nerves, marking a shift from previous studies that used fibroblast-derived iPS cells.
  • They identified and reprogrammed p75NTR-positive iris stem/progenitor cells, successfully creating iris-derived iPS (H-iris iPS) cells that displayed pluripotency and formed different cell types.
  • The study demonstrated that H-iris iPS cells could differentiate into functional retinal neurons, showing potential for regenerative treatments in ophthalmology.
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  • The study found that nuclear cataracts are more common in residents of tropical and subtropical regions compared to those in cooler areas, possibly due to higher environmental temperatures.
  • Researchers simulated human lens temperatures and discovered that higher temperatures (37.5 °C) led to increased RNA synthesis and protein expression in a specific cell line associated with cataract development.
  • The findings suggest that long-term exposure to elevated temperatures may heighten the risk of developing cataracts due to enhanced secretion of amyloid beta (Aβ) in lens cells.
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Recent epidemiological studies have hypothesized that the prevalence of cortical cataracts is closely related to ultraviolet radiation. However, the prevalence of nuclear cataracts is higher in elderly people in tropical areas than in temperate areas. The dominant factors inducing nuclear cataracts have been widely debated.

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Purpose: To investigate the distribution of corneal spherical aberration (SA) in Tanzanian people of African descent, and to examine the correlation between corneal SA and ocular parameters.

Design: Cross-sectional population-based study.

Methods: Residents aged 40 years and older in three villages in the Mkuranga district in Tanzania were enlisted as study participants.

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Purpose: To investigate visual function in eyes with three subtypes of waterclefts (WCs).

Methods: Of patients in Kanazawa Medical University Hospital (2013-2017) and participants of Monzen Eye Study (2013-2016), 77 transparent lenses, mean age 66.7 years, and 70 eyes with only WC opacity of 70 patients, mean age 68.

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  • The text indicates that a correction has been made to the article with the DOI 10.1371/journal.pone.0215338.
  • This correction highlights important amendments or updates that affect the original research findings.
  • Readers are advised to refer to the corrected version for accurate information and conclusions drawn in the study.
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Purpose: We investigated associations between ocular ultraviolet (UV) radiation exposure dose and cataract opacities among Han people living in China and Taiwan, to assess the effects of UV exposure intensity.

Methods: This cross-sectional study included Han people aged ≥40 years (1,801 individuals, 450 in Sanya, 636 in Taiyuan, and 715 in Taichung) as subjects who completed a questionnaire including items about diabetes, smoking, steroid use, work history, and time spent outdoors, and underwent an ophthalmic examination. Right eye axial length was measured using A-mode ultrasonography or IOLMaster.

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Purpose: To determine whether subsurface nanoglistening in hydrophobic acrylic intraocular lenses (IOL) diminishes visual performance.

Setting: Department of Ophthalmology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.

Design: Experimental study.

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Purpose: To compare and evaluate changes in the retinal image with age in Japanese adults with transparent crystalline lenses.

Setting: Shibuya-ku, Tokyo, Japan.

Design: Cross-sectional study.

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Purpose: To assess the validity of the solar ultraviolet index (UVI) as a determiner of eye risk under different conditions of facial profiles and orientation, and reflected light.

Methods: Ocular UV radiation (UVR) exposure was measured as a function of the time of the day (solar altitude) using a two-dummy-type mannequin dosimetry system with embedded UVR (260-310 nm) sensors, in September and November in Kanazawa, Japan, on a motorized sun-tracking mount with one dummy face directed toward the sun and the other away from the sun.

Results: A bimodal distribution of UV-B exposure was found in September for the face directed toward the sun, which differed dramatically from the pattern of ambient UVR exposure and measurements taken on the top of the head and those for the eye taken later in the year.

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