Publications by authors named "Natsuki Takashima"
Extremophiles
January 2019
Article Synopsis
- DNA polymerase D (PolD) is a unique enzyme found in most archaea, except the Crenarchaeota phylum, and is composed of two proteins, DP1 and DP2.
- A method was developed to purify PolD from Thermococcus kodakarensis, revealing that DP1 and DP2 form a stable 1:1 complex, despite DP1 having an intrinsically disordered region.
- The study indicates that while DP2 has a strong DNA-binding capability, DP1 has a weak affinity for DNA, and both proteins are essential for DNA synthesis and degradation activities.
