Publications by authors named "Natsuki Minamikawa"
Immunostimulatory effects of Heyndrickxia coagulans SANK70258.
Biosci Biotechnol Biochem
December 2024
Here, we examined the immunomodulating effects of Heyndrickxia coagulans SANK70258 (SANK70258). Mouse splenocytes treated with γ-ray-irradiated SANK70258 produced higher levels of IFN-γ than those with 7 types of lactic acid bacteria. IFN-γ was mainly produced by NK cells, involving IL-12/IL-23, dendritic cells (DCs), and NFκB signaling.
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- Various gut bacteria can convert polyunsaturated fatty acids into different types of fatty acid derivatives, with γKetoC identified as a potent immunomodulator that inhibits inflammation and immune cell activation.
- γKetoC reduces the proliferation of CD4 T cells and the release of inflammatory cytokines in various immune cell types, indicating its potential therapeutic effects on inflammation.
- The study highlights the role of the NRF2 pathway and GPR40/120 receptors in mediating the anti-inflammatory responses of γKetoC, demonstrating improved outcomes in mice with colitis while showing adverse effects in NRF2-deficient mice.