Novel role of homogalacturonan region of pectin in disrupting the interaction between fibronectin and integrin β1.

Pectin interacts with fibronectin (FN), a modular protein in the extracellular matrix. This interaction is significant as FN plays a pivotal role by binding to the receptor integrin α5β1. However, the molecular mechanism underlying the pectin-FN interaction and its impact on integrin binding remains unknown.