Publications by authors named "Natsue Uehiro"
Background: Data on the desire for pregnancy and the status of fertility preservation (FP) in patients with breast cancer remain unclear. This study aimed to determine the status of patients with breast cancer who desired pregnancy and FP implementation before systemic therapy.
Methods: This retrospective study surveyed the institutional clinical databases and electronic medical records of patients aged < 43 years with stages 0-III primary breast cancer during surgery and treated between April 2020 and March 2021.
Background: The number of breast cancer patients of childbearing age has been increasing. Therefore, we investigated the characteristics and the childbearing status of the patients who received systemic therapy for breast cancer during their childbearing age to better understand the clinical impact of childbirth.
Methods: Female patients with breast cancer younger than 40 years old who underwent surgery and received perioperative systemic therapy from 2007 to 2014 were included in this study.
Article Synopsis
- The study explored whether smartphone apps focusing on problem-solving therapy and behavioral activation could help breast cancer survivors manage fear of cancer recurrence (FCR).
- The randomized trial involved 447 participants who either used the apps or were in a waitlist control group, with outcomes measured after 8 and 24 weeks.
- Results indicated that the intervention group experienced significant improvements in FCR and related psychological factors after 8 weeks, suggesting that smartphone therapy could be an effective support tool for a large population of survivors.
Clinical significance of the neutrophil-to-lymphocyte ratio in oligometastatic breast cancer.
Breast Cancer Res Treat
November 2022
Purpose: This study investigated the clinical impact of pretreatment neutrophil-to-lymphocyte ratio (NLR) on survival in patients with oligometastatic breast cancer.
Patients And Methods: We collected data from 397 patients who underwent primary breast surgery from 2004 to 2015 and developed recurrence during the follow-up. We reviewed the images and clinical information and defined OMD according to the European Society for Medical Oncology advanced breast cancer guidelines.
Article Synopsis
- - The study examines pregnancy-associated breast cancer (PABC), which includes breast cancer diagnosed during pregnancy and up to a year after childbirth, focusing on treatment trends and long-term outcomes.
- - It found that patients diagnosed with breast cancer after childbirth (LBC) tend to have more severe clinical characteristics and poorer survival rates compared to those diagnosed during pregnancy (PBC), particularly between surgeries performed before and after 2005.
- - The conclusion emphasizes that early detection and better systemic treatment strategies are essential for improving the prognosis of LBC patients, as their worse outcomes are largely attributed to more advanced disease at the time of diagnosis rather than inherent biological factors.
Background: Circulating cell-free DNA (cfDNA) has recently been recognized as a resource for biomarkers of cancer progression, treatment response, and drug resistance. However, few have demonstrated the usefulness of cfDNA for early detection of cancer. Although aberrant DNA methylation in cfDNA has been reported for more than a decade, its diagnostic accuracy remains unsatisfactory for cancer screening.
View Article and Find Full Text PDFBackground: The aim of this study was to extensively analyze the signaling pathway molecules in breast cancer and to explore candidate biomarkers for clinicopathological relevance.
Methods: We assessed the expression of key factors in cell signaling, namely p-AKT, cyclin D1, P27, p-p70S6 K, p-4EBP1, and p-MAPK/ERK, within 338 invasive breast cancer patients. These factors were immunohistochemically examined in tumor tissues and assessed by staining score.
Background: The TNM classification of the Unio Internationalis Contra Cancrum was revised for the seventh edition. The major change concerning breast cancer is a change in the stages for patients with T0 or T1N1miM0. In the present study, the seventh edition of the TNM classification was validated in breast cancer.
View Article and Find Full Text PDF