Publications by authors named "Natpapat Kaewkhao"
Article Synopsis
- - The study focused on developing a highly sensitive and automated method to measure ivermectin levels in plasma and whole blood samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
- - A solid-phase extraction technique was employed to eliminate phospholipids from blood samples, and the method demonstrated effective separation and detection of ivermectin without interference.
- - Validation results confirmed the method's accuracy and reliability, making it suitable for clinical use and further research involving ivermectin quantification in blood samples.
A high-throughput LC-MS/MS assay for piperaquine from dried blood spots: Improving malaria treatment in resource-limited settings.
J Mass Spectrom Adv Clin Lab
January 2024
Background: Malaria is a parasitic disease that affects many of the poorest economies, resulting in approximately 241 million clinical episodes and 627,000 deaths annually. Piperaquine, when administered with dihydroartemisinin, is an effective drug against the disease. Drug concentration measurements taken on day 7 after treatment initiation have been shown to be a good predictor of therapeutic success with piperaquine.
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