Publications by authors named "Natorska J"
Exercise stress test-induced hypofibrinolysis and changes in circulating levels of several interleukins have been observed in aortic stenosis (AS). However, it is unknown whether the pattern of exercise-induced changes in oxidative stress differs between AS patients and controls and if the differences are associated with changes in fibrinolysis and inflammation. We studied 32 asymptomatic patients with moderate-to-severe AS and 32 controls of similar age, sex, and body mass index.
View Article and Find Full Text PDFNovel factors affecting fibrin clot formation and their clinical implications.
Pol Arch Intern Med
December 2024
Fibrin formation is pivotal in hemostasis, serving as a temporary barrier to blood loss following vascular injury, while in thrombosis this process is involved in thrombus progression, stability, and recurrence. Growing evidence shows exceptional complexity of processes that determine fibrin clot structure and function, especially lysability, both in health and disease, which might be relevant in the pathogenesis of arterial and venous thromboembolic diseases. In this review, we summarized available data on novel factors that in recent years have been suggested to contribute to prothrombotic fibrin clot properties, involving formation of compact fibrin networks (reduced clot permeability) displaying impaired susceptibility to lysis (prolonged clot lysis time).
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- The study aimed to investigate how high-dose statins impact the formation of neutrophil extracellular traps (NETs) in patients with coronary artery disease (CAD).
- A group of 130 patients was monitored before and after starting statin therapy, revealing significant reductions in proteins linked to NETs, such as citrullinated histone H3, myeloperoxidase, and neutrophil elastase.
- These reductions correlated with decreased inflammation markers and changes that suggest improved clot formation properties, indicating that statins may have beneficial effects beyond just lowering LDL cholesterol.
Context.—: A positive association between antithrombin activity and selenium level was reported. Selenoprotein P, the most important selenium carrier, was identified within human plasma fibrin clots.
View Article and Find Full Text PDFBackground: Increased clot permeability and susceptibility to lysis have been reported in women with heavy menstrual bleeding. We hypothesized that similar alterations in fibrin clot properties may also be present in women with postpartum hemorrhage (PPH) of unknown cause.
Objective: To determine fibrin clot properties and their determinants in women after PPH of unknown cause.
Background: Gut dysbiosis leading to increased intestinal barrier permeability and translocation of lipopolysaccharide (LPS) in the circulation has been demonstrated in patients with acute myocardial infarction and pulmonary embolism.
Objectives: We investigated changes in circulating LPS concentrations in acute ischemic stroke (AIS) and their consequences, including prognosis.
Methods: We studied 98 AIS patients, aged 74 ± 12 years, including 74 (75.
Article Synopsis
- - The study aimed to determine if evaluating brain injury markers (S100B, NSE, GFAP) alongside clinical scores (APACHE II, SAPS II, SOFA) could better predict mortality in patients with septic shock.
- - In a trial with 55 septic shock patients, it was found that higher levels of S100B and NSE correlated with increased mortality, but NSE was particularly good at predicting death risk.
- - Combining S100B and CRP levels with the APACHE II score improved mortality prediction accuracy to 95%, suggesting that assessing neuronal injury is crucial for assessing prognosis in septic shock patients.
Article Synopsis
- Hormone therapy (HT) is shown to decrease protein carbonylation (PC) and improve clot lysis in postmenopausal women, who generally have issues with fibrinolysis.
- In a study with 150 women, those with higher baseline PC (above 2.07 nM/mg) experienced longer clot lysis times and increased prothrombotic markers, while HT reduced PC and improved clot lysis rates.
- The findings suggest that HT effectively lowers PC levels and enhances fibrinolysis in postmenopausal women with elevated PC, regardless of the type of HT used.
Article Synopsis
- - This study examines the relationship between plasma protein carbonyls (PC), which indicate oxidative stress, and the risk of ischemic stroke in atrial fibrillation (AF) patients on anticoagulation therapy.
- - Researchers analyzed data from 243 AF patients over a median follow-up of 53 months, finding that higher baseline PC levels were significantly associated with increased stroke risk, even after accounting for other factors.
- - The results suggest that elevated protein carbonylation in AF patients may contribute to a higher "residual" stroke risk, possibly due to changes in fibrin clot characteristics despite being on anticoagulant medication.
Background: Antiphospholipid antibodies (aPL), including lupus anticoagulant, antibodies against β glycoprotein I (anti-β2GPI), and anticardiolipin (aCL) antibodies are associated with ischemic stroke (IS). Their prevalence and clinical relevance in atrial fibrillation (AF) remain unclear.
Objectives: To assess whether aPL are associated with increased risk of IS in AF patients despite anticoagulation.
Background: Little is known about the role of complement activation in acute pulmonary embolism (PE). We investigated whether complement activation is associated with the severity of acute PE, along with the associated prothrombotic state, systemic inflammation and neutrophil extracellular traps (NETs) formation.
Methods: We studied 109 normotensive, non-cancer PE patients (aged 58.
Introduction: The SERPINE1 c.-820G (4_5), MTHFR gene variants, and unfavourably altered fibrin clot features, have been suspected to be associated with embolic stroke of undetermined source (ESUS). We investigated the SERPINE1 c.
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- A study explored how left atrial appendage (LAA) occlusion affects blood coagulation parameters over six months, revealing potential patient benefits.
- The research involved 22 patients, analyzing changes in various coagulation factors and dividing them into subgroups based on LAA size.
- Findings showed that patients with normal LAA size experienced significant decreases in most clotting factors, while those with enlarged LAA benefited differently, highlighting the importance of LAA morphology in managing coagulation stability.
Article Synopsis
- * NET formation (NETosis) is associated with serious conditions like coronary artery disease, heart failure, and stroke, worsening outcomes through mechanisms such as plaque rupture and increased infarct size.
- * Potential treatments targeting NETs, such as DNase and other drugs to inhibit excessive NETosis, are being explored to improve clinical outcomes in patients with CVDs.
Article Synopsis
- Eosinophilic granulomatosis with polyangiitis (EGPA) is linked to a prothrombotic state, and this study aims to explore the role of coagulation factors FXI and FXII in this context.
- In a sample of 34 EGPA patients in remission, elevated levels of FXI were found to correlate with higher eosinophil counts and altered fibrin clot characteristics, indicating a connection between FXI levels and prothrombotic conditions.
- The findings suggest that targeting FXI could be beneficial for treating prothrombotic states in patients with EGPA, especially those exhibiting hypereosinophilia, making it a potential focus for future therapies.
Thrombosis and Aging: Fibrin Clot Properties and Oxidative Stress.
Antioxid Redox Signal
August 2024
Aging is a complex process associated with an increased risk of many diseases, including thrombosis. This review summarizes age-related prothrombotic mechanisms in clinical settings of thromboembolism, focusing on the role of fibrin structure and function modified by oxidative stress. Aging affects blood coagulation and fibrinolysis multiple mechanisms, including enhanced oxidative stress, with an imbalance in the oxidant/antioxidant mechanisms, leading to loss of function and accumulation of oxidized proteins, including fibrinogen.
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- The study investigates how levels of phoenixin (PNX-14), nesfatin-1 (NES-1), dopamine (DA), and oxytocin (OT) relate to pregnancy rates in women undergoing ovarian stimulation (OS).
- A total of 56 infertile women under 40, with specific reproductive health conditions, participated; blood samples were taken before and during the stimulation process to measure hormone levels and monitor pregnancy outcomes.
- Results indicated that pregnant women had higher baseline NES-1 and OT levels, while also showing that elevated PNX-14 and DA, along with lower OT, are associated with successful pregnancies following ovarian stimulation.
Article Synopsis
- Lipopolysaccharide (LPS), which can enter the bloodstream and cause inflammation, was studied in 120 normotensive patients with acute pulmonary embolism (PE) to see if its levels are linked to a prothrombotic state.
- The study found that higher LPS levels on admission correlated with increased inflammation and clotting factors, particularly in patients with more severe PE.
- Over time, LPS and gut permeability (measured by zonulin) levels decreased significantly with anticoagulation treatment, suggesting that low-grade endotoxemia may play a role in increased thrombin generation and impaired clot breakdown in acute PE patients.
Background: Residual pulmonary vascular obstruction (RPVO) is common following pulmonary embolism (PE) but its association with fibrin clot properties is poorly understood. We investigated whether prothrombotic state and hypofibrinolysis markers can identify patients with RPVO.
Methods: In 79 normotensive noncancer patients (aged 56 ± 13.