Publications by authors named "Nato Narsia"
Transcriptome analysis reveals distinct gene expression profiles in astrocytoma grades II-IV.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
September 2017
Article Synopsis
- Astrocytoma is the most common primary brain cancer, divided into four grades recognized by the WHO, and research aims to better understand the mechanisms that differentiate these grades for targeted therapies.
- A study analyzed RNA sequencing data from various astrocytoma grades and normal brain samples to find gene expression differences, revealing unique patterns between lower-grade and higher-grade tumors.
- The findings highlight specific genes and pathways involved in tumor growth and spread, suggesting that understanding these molecular processes can enhance the knowledge of glioma biology and inform future treatment strategies.
Tumors are not merely masses of neoplastic cells but complex tissues composed of cellular and noncellular elements. This review provides recent data on the main components of a dynamic system, such as carcinoma associated fibroblasts that change the extracellular matrix (ECM) topology, induce stemness and promote metastasis-initiating cells. Altered production and characteristics of collagen, hyaluronan and other ECM proteins induce increased matrix stiffness.
View Article and Find Full Text PDF