Publications by authors named "Natnael Doilicho"
Article Synopsis
- Patients with focal temporal lobe seizures often lose consciousness, showing brain activity similar to deep sleep.
- Previous studies in rats suggest that reduced arousal in the brain leads to decreased brain function during these seizures, but they didn't connect this to conscious behavior.
- In this study using awake mice, researchers found that seizures affect behavior, particularly responses to sounds, by altering acetylcholine levels in the brain, highlighting the link between reduced brain activity and loss of consciousness during these episodes.
Background: After kidney injury, macrophages transition from initial proinflammatory activation to a proreparative phenotype characterized by expression of arginase-1 (), mannose receptor 1 (), and macrophage scavenger receptor 1 (). The mechanism by which these alternatively activated macrophages promote repair is unknown.
Methods: We characterized the macrophage and renal responses after ischemia-reperfusion injury with contralateral nephrectomy in mice and littermate controls and used coculture of macrophages and tubular cells to determine how macrophage-expressed arginase-1 promotes kidney repair.
Background: Bordetella bronchiseptica is a gram-negative, obligate aerobic coccobacillus known to cause disease in domesticated animals and pets. In humans, B. bronchiseptica commonly leads to respiratory infections like pneumonia or bronchitis, and animal contact usually precedes the onset of symptoms.
View Article and Find Full Text PDFBackground: Driveline infection (DLI) is the most common left ventricular assist device (LVAD) infectious complication. Short-term antimicrobial therapy and local debridement are the cornerstones of management for these infections, but the use of chronic antimicrobial suppression (CAS) therapy is not well characterized.
Methods: To better characterize the efficacy of CAS therapy, we performed a retrospective review of all patients (N = 219) receiving care at our tertiary transplant center with continuous-flow LVADs placed between August 2007 and July 2019.
Left ventricular assist devices (LVADs) are integral for the management of medically refractory heart failure, and LVAD infections are common following device placement. Most infections are caused by Staphylococcal spp. and Gram-negative enteric bacteria but nontuberculous mycobacterial (NTM) infections have been reported.
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