Publications by authors named "Natnael D Kenea"
Diarrheal diseases claim the lives of 1300 children daily, mostly in the developing world. We have developed a simple lateral flow assay capable of detecting and EPEC DNA and RNA rapidly (<15 minutes) at the point-of-need, directly from stool without nucleic acid extraction or molecular amplification. The limit of detection of the method is 1 nM using synthetic DNA target substrates spiked into stool.
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- The study examines how certain microRNAs (miRs) are involved in changes to the intestinal barrier that are linked to fatty liver disease and metabolic syndrome.
- Researchers transfected specific miR mimics into human colorectal cells and monitored changes in miR expression, cell barrier function, and tight junction structures.
- The findings reveal significant alterations in miR expression, emphasizing a signaling network related to inflammation and cellular damage that could contribute to the pathogenesis of these metabolic conditions.
Colonic epithelial health is implicated in a host of gastrointestinal (GI) diseases and disorders. Lysozyme is suspected to play a role in the ability of the epithelium to recover from injury (Abey et al., in press; Gallo, 2012; Rubio, 2014) [1], [2], [3].
View Article and Find Full Text PDFBackground: Stress has demonstrated effects on inflammation though underlying cell-cell communication mechanisms remain unclear. We hypothesize that circulating RNAs and extracellular vesicles (EVs) in patients with chronic stress contain signals with functional roles in cell repair.
Methods: Blood transcriptome from patients with Irritable Bowel Syndrome versus controls were compared to identify signaling pathways and effectors.