Publications by authors named "Natividad Cuadrado-Corrales"

: The objective of this study was to compare trends in the incidence of deliveries and in obstetric interventions and outcomes in women with and without type 1 diabetes (T1DM), type 2 diabetes (T2DM), and gestational diabetes (GDM). : This was an observational study using the Spanish National Hospital Discharge Database (2016-2022). : A total of 1,995,953 deliveries were recorded between 2016 and 2022 (6495 mothers with T1DM, 5449 with T2DM, and 124,172 with GDM).

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(1) Background: To describe hospitalizations due to respiratory syncytial virus (RSV) infection among children and elderly patients with asthma. (2) Methods: We used a nationwide discharge database to select patients with asthma aged 0 to 15 years and ≥65 years admitted to Spanish hospitals from 2016 to 2022. (3) Results: We identified 49,086 children and 471,947 elderly patients hospitalized with asthma (3.

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: To analyze the number and clinical characteristics of hospital admissions in Spain between 2016 and 2022 in which alpha-1-antitrypsin deficiency (AATD) was coded; to describe and analyze differences in these parameters between men and women; and to identify variables associated with a worse prognosis. : We used a nationwide discharge database to select all admissions featuring an AATD diagnostic code (ICD-10 code E88.01) in any position.

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  • Radical prostatectomy often leads to erectile dysfunction (ED), and this study aimed to see if certain biological markers linked to ED could be found in buccal mucosa (cheek tissue) of patients.
  • Before and one year after surgery, erectile function was assessed in 38 men, measuring the expression of nitric oxide synthase, soluble guanylate cyclase, phosphodiesterase-5, and inflammation markers.
  • Results indicated that patients with ED had higher levels of PDE-5 in their buccal mucosa compared to those who recovered erectile function, but there were no differences in other markers or in the genetic variation related to PDE-5.
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(1) Background: Artificial intelligence using machine learning techniques may help us to predict and prevent obesity. The aim was to design an interpretable prediction algorithm for overweight/obesity risk based on a combination of different machine learning techniques. (2) Methods: 38 variables related to sociodemographic, lifestyle, and health aspects from 1179 residents in Madrid were collected and used to train predictive models.

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Background: We used the Spanish national hospital discharge data from 2016 to 2022 to analyze procedures and hospital outcomes among patients aged ≥ 18 years admitted for ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) according to diabetes mellitus (DM) status (non-diabetic, type 1-DM or type 2-DM).

Methods: We built logistic regression models for STEMI/NSTEMI stratified by DM status to identify variables associated with in-hospital mortality (IHM). We analyzed the effect of DM on IHM.

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  • The study analyzes hospitalizations for Creutzfeldt-Jakob disease (CJD) and fatal familial insomnia (FFI) in Spain from 2016 to 2022, identifying 1063 discharges, with a majority for CJD.
  • There was a notable increase in FFI cases in 2017, with average hospital stays of 13 days for CJD and 6 days for FFI; the in-hospital mortality rates were 36.37% for CJD and 32.56% for FFI.
  • Factors like older age and the presence of sepsis or pneumonia were linked to higher mortality rates in CJD patients, and the total cost for managing these diseases during the study was approximately EUR
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Introduction: The objectives of this study were to examine temporal trends in the incidence of bariatric surgery (Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG)) in patients with and without type 2 diabetes mellitus (T2DM). Outcomes of hospitalization and the impact of T2DM on these outcomes were also analyzed.

Research Design And Methods: We performed an observational study with the Spanish national hospital discharge database.

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Background: Food-induced anaphylaxis (FIA) is a major public health problem resulting in serious clinical complications, emergency department visits, hospitalization, and death.

Objective: This study aims to assess the epidemiology and the trends in hospitalizations because of FIA in Spain between 2016 and 2021.

Methods: An observational descriptive study was conducted using data from the Spanish National Hospital discharge database.

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  • The study analyzed the prevalence and outcomes of atrial fibrillation (AF) in patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) in Spain from 2016 to 2021.
  • It found that 20.58% of hospitalized patients had AF, with a notable increase in prevalence over the years, especially in men.
  • Patients with AF faced longer hospital stays and higher in-hospital mortality rates, influenced by factors such as older age, male sex, comorbidities including COVID-19, and the need for intensive care.
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  • The study analyzed trends in kidney transplants (KT) among patients with type 1 diabetes (T1D), type 2 diabetes (T2D), and those without diabetes from 2016 to 2020 in Spain, focusing on incidence, complications, and hospital outcomes.
  • Results showed a decline in KTs during the COVID-19 pandemic, with an increase in complications for T2D patients and higher rates of organ rejection for T1D patients.
  • T1D was linked to higher in-hospital mortality rates, while T2D did not show a similar association, suggesting different impacts of diabetes types on transplant outcomes.
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  • This study aimed to analyze the prevalence of atrial fibrillation (AF) among asthma patients hospitalized in Spain and compare hospital outcomes based on AF presence, with a focus on sex differences and factors linked to hospital mortality.
  • Researchers examined data from over 65,000 hospitalizations between 2016 and 2021, finding that nearly 15% of asthma patients had AF, which increased over time, while male patients had a lower risk of developing AF.
  • The study concluded that AF in asthma patients led to higher in-hospital mortality rates, especially in older patients and those with additional health conditions, and noted that sex did not have an impact on mortality rates in this group.
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  • Anaphylaxis is a serious and quick-reaction allergic response, and this study looked at adult hospitalizations in Spain from 2016 to 2021, specifically comparing patients with asthma to those without.
  • The analysis used data from a national database and included matching patients to accurately evaluate their conditions and outcomes.
  • Findings revealed that the number of hospitalizations remained stable, but drug-induced anaphylaxis rose; while asthma patients had more respiratory issues, overall mortality rates didn’t differ much between asthma and non-asthma patients, highlighting the need for further research into the complexities of anaphylaxis.
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(1) Background: Worldwide, asthma, back pain, and migraine are major public health problems due to their high prevalence, effect on the quality of life, and huge economic costs. The association of asthma with an increased risk of these types of pain has been suggested; however, no conclusive results have been obtained to date. The aims of our study were (1) to describe and compare the prevalence of three types of pain localization, namely migraine or frequent headaches (MFH), chronic neck pain (CNP), and chronic low back pain (CLBP), in adults with and without asthma in Spain during the years 2014 and 2020 and (2) to identify which variables were associated with the presence of these types of pain in adults with asthma.

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(1) Background: We analyzed the association between atrial fibrillation or atrial flutter (AF) and in-hospital mortality (IHM) among patients who underwent solid organ transplants in Spain from 2004 to 2021. (2) Methods: We gathered information from all hospital admissions for lung, liver, kidney, and heart transplants. (3) Results: A total of 71,827 transplants were analyzed (4598 lung transplants; 18,127 liver transplants; 45,262 kidney transplants; and 4734 heart transplants).

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  • The study analyzes trends in physical activity (PA) among individuals with chronic obstructive pulmonary disease (COPD) in Spain from 2014 to 2020, focusing on sex differences and socio-demographic factors.
  • Self-reported levels of PA remained stable, but more people reported walking frequently, and men with COPD were more active than women.
  • The findings indicate that even though there’s a positive trend in PA, COPD patients still have lower activity levels compared to those without the condition, with factors like age, education, and health status influencing activity levels.
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(1) Background: To assess and compare the temporal trends in the incidence, characteristics and hospital outcomes among children with and without asthma who were hospitalized with anaphylaxis in Spain from 2016 to 2021, and identify the variables associated with severe anaphylaxis among children with asthma. (2) Methods: An observational, retrospective study was conducted using a population-based database. The study population included pediatric patients with anaphylaxis.

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Background: The impact of Type 2 Diabetes (T2D) on the outcomes of heart transplantation (HT) has not yet been clearly established. The objectives of this study were to examine the trends in the prevalence of T2D among individuals who underwent a HT in Spain from 2002 to 2021, and to compare the clinical characteristics and hospitalization outcomes between HT recipients with and without T2D.

Methods: We used the national hospital discharge database to select HT recipients aged 35 and older.

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(1) Background: Epidermolysis bullosa (EB) comprises a group of rare skin diseases. We assessed diagnostic procedures, comorbidity profiles, length of hospital stay (LOHS), costs, and in-hospital mortality (IHM) associated with EB. (2) Methods: A retrospective, population-based observational study was performed using the Spanish National Hospital Discharge Database.

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(1) Background: To analyze the association between hospital-acquired pneumonia (HAP) and in-hospital mortality (IHM) during hospital admission for solid organ transplant in Spain during 2004-2021. (2) Methods: We used national hospital discharge data to select all hospital admissions for kidney, liver, heart, and lung transplants. We stratified the data according to HAP status.

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(1) Background: This paper aims to assess temporal trends (2016-2020) in incidence, patient's characteristics, complications, length of hospital stay (LOHS) and in-hospital mortality (IHM) among patients with and without idiopathic pulmonary fibrosis (IPF) undergoing lung transplantation (LTx). We also analyse the effect of the COVID-19 pandemic on LTx in these populations. (2) Methods: A retrospective, population-based observational study was conducted using the Spanish National Hospital Discharge Database.

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(1) Background: We aim to assess the time trend from 2014 to 2020 in the prevalence of physical activity (PA), identify gender differences and sociodemographic and health-related factors associated with PA among people with diabetes, and compare PA between people with and without diabetes. (2) Methods: We conducted a cross-sectional and a case-control study using as data source the European Health Interview Surveys for Spain (EHISS) conducted in years 2014 and 2020. The presence of diabetes and PA were self-reported.

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(1) Background: To assess changes in the prevalence of dementia among patients hospitalized with type 2 diabetes (T2DM), to analyze the effects of dementia on in-hospital mortality (IHM) in this population, to evaluate sex differences, and to determine the impact of the COVID-19 pandemic on these parameters. (2) Methods: We used a nationwide discharge database to select all patients with T2DM aged 60 years or over admitted to Spanish hospitals from 2011 to 2020. We identified those with all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD).

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  • The study aimed to analyze how dementia prevalence affects hospital outcomes for patients with acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) in Spain from 2011 to 2020, focusing on sex differences and the impact of the COVID-19 pandemic.
  • Researchers used a nationwide discharge database, revealing that 4.45% of the 658,429 AE-COPD hospitalizations involved patients with some type of dementia, with trends showing an increase in dementia cases from 2016 to 2020.
  • In-hospital mortality rates remained stable until 2020, when they rose significantly, likely due to COVID-19; the study also noted that women had lower mortality risks compared
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  • The study investigates the clinical characteristics and outcomes of lung transplantation in COPD patients in Spain from 2016 to 2020, focusing on the impact of the COVID-19 pandemic on these metrics.
  • A total of 704 lung transplants were analyzed, revealing an annual increase until 2019, followed by an 18% decline in 2020; common complications included transplant rejection and infection, affecting nearly half of the patients.
  • The research found that while the overall number of transplantations decreased in 2020, there were no significant changes in median hospital stay or in-hospital mortality rates compared to previous years.
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